HA2S_MOUSE
ID HA2S_MOUSE Reviewed; 233 AA.
AC P14437;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=H-2 class II histocompatibility antigen, A-S alpha chain;
GN Name=H2-Aa;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2581258; DOI=10.1073/pnas.82.9.2930;
RA Landais D., Matthes H., Benoist C., Mathis D.;
RT "A molecular basis for the Ia.2 and Ia.19 antigenic determinants.";
RL Proc. Natl. Acad. Sci. U.S.A. 82:2930-2934(1985).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, Kidney, Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MHC class II family. {ECO:0000305}.
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DR EMBL; M11358; AAA39622.1; -; mRNA.
DR PIR; I79358; I79358.
DR AlphaFoldDB; P14437; -.
DR SMR; P14437; -.
DR PhosphoSitePlus; P14437; -.
DR MaxQB; P14437; -.
DR PRIDE; P14437; -.
DR ProteomicsDB; 269807; -.
DR MGI; MGI:95895; H2-Aa.
DR ChiTaRS; H2-Aa; mouse.
DR Proteomes; UP000000589; Unplaced.
DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005764; C:lysosome; IDA:MGI.
DR GO; GO:0042613; C:MHC class II protein complex; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR GO; GO:0042605; F:peptide antigen binding; IDA:MGI.
DR GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0019882; P:antigen processing and presentation; IDA:MGI.
DR GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IDA:MGI.
DR GO; GO:0048002; P:antigen processing and presentation of peptide antigen; IDA:MGI.
DR GO; GO:0042130; P:negative regulation of T cell proliferation; ISO:MGI.
DR GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR GO; GO:0045582; P:positive regulation of T cell differentiation; IDA:MGI.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.10.320.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR001003; MHC_II_a_N.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00993; MHC_II_alpha; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00920; MHC_II_alpha; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF54452; SSF54452; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW Adaptive immunity; Disulfide bond; Glycoprotein; Immunity; Membrane;
KW MHC II; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..233
FT /note="H-2 class II histocompatibility antigen, A-S alpha
FT chain"
FT /id="PRO_0000080748"
FT TOPO_DOM 1..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 222..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 91..183
FT /note="Ig-like C1-type"
FT REGION 1..88
FT /note="Alpha-1"
FT REGION 89..182
FT /note="Alpha-2"
FT REGION 183..195
FT /note="Connecting peptide"
FT CARBOHYD 122
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 111..167
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 233 AA; 25801 MW; 6652ED01A87F3019 CRC64;
EDDIEADHVG VYGTTVYQSP GDIGQYTHEF DGDEWFYVDL DKKETIWMLP EFGQLTSFDP
QGGLQNIATG KYTLGILTKR SNSTPATNEA PQATVFPKSP VLLGQPNTLI CFVDNIFPPV
INITWLRNSK SVTDGVYETS FLVNRDHSFH KLSYLTFIPS DDDIYDCKVE HWGLEEPVLK
HWEPEIPAPM SELTETVVCA LGLSVGLVGI VVGTIFIIQG LRSGGTSRHP GPL
