ID   HABP4_CHICK             Reviewed;         357 AA.
AC   Q9I9R0;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Intracellular hyaluronan-binding protein 4 {ECO:0000250|UniProtKB:Q5JVS0};
DE            Short=IHABP4 {ECO:0000250|UniProtKB:Q5JVS0};
GN   Name=HABP4 {ECO:0000250|UniProtKB:Q5JVS0};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAF36965.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RX   PubMed=10887182; DOI=10.1074/jbc.m002737200;
RA   Huang L., Grammatikakis N., Yoneda M., Banerjee S.D., Toole B.P.;
RT   "Molecular characterization of a novel intracellular hyaluronan-binding
RT   protein.";
RL   J. Biol. Chem. 275:29829-29839(2000).
CC   -!- FUNCTION: RNA-binding protein that plays a role in the regulation of
CC       transcription, pre-mRNA splicing and mRNA translation.
CC       {ECO:0000250|UniProtKB:A1L1K8, ECO:0000250|UniProtKB:Q5JVS0}.
CC   -!- SUBUNIT: Associates with polysomes. {ECO:0000250|UniProtKB:Q5JVS0}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5JVS0}. Cytoplasm
CC       {ECO:0000269|PubMed:10887182}. Cytoplasm, Stress granule
CC       {ECO:0000250|UniProtKB:Q5JVS0}. Cytoplasm, sarcoplasm
CC       {ECO:0000250|UniProtKB:A1L1K8}. Nucleus, nuclear body
CC       {ECO:0000250|UniProtKB:Q5JVS0}. Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q5JVS0}. Nucleus speckle
CC       {ECO:0000250|UniProtKB:Q5JVS0}. Nucleus, Cajal body
CC       {ECO:0000250|UniProtKB:Q5JVS0}. Nucleus, gem
CC       {ECO:0000250|UniProtKB:Q5JVS0}. Note=Predominantly cytoplasmic.
CC       {ECO:0000269|PubMed:10887182}.
CC   -!- DOMAIN: The C-terminal region is necessary for nucleus and cytoplasmic
CC       localization. The N-terminal region is necessary for nucleus and
CC       nuclear bodies localization. {ECO:0000250|UniProtKB:Q5JVS0}.
CC   -!- MISCELLANEOUS: Able to bind hyaluronan. However, its intracellular
CC       localization suggests that this interaction may not be relevant in
CC       vivo. {ECO:0000305}.
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DR   EMBL; AF227683; AAF36965.1; -; mRNA.
DR   RefSeq; NP_990036.1; NM_204705.1.
DR   AlphaFoldDB; Q9I9R0; -.
DR   STRING; 9031.ENSGALP00000020585; -.
DR   PaxDb; Q9I9R0; -.
DR   Ensembl; ENSGALT00000020614; ENSGALP00000020585; ENSGALG00000012628.
DR   GeneID; 395444; -.
DR   KEGG; gga:395444; -.
DR   CTD; 22927; -.
DR   VEuPathDB; HostDB:geneid_395444; -.
DR   eggNOG; KOG2945; Eukaryota.
DR   GeneTree; ENSGT00520000055591; -.
DR   HOGENOM; CLU_037366_0_0_1; -.
DR   InParanoid; Q9I9R0; -.
DR   OrthoDB; 1183388at2759; -.
DR   PhylomeDB; Q9I9R0; -.
DR   Reactome; R-GGA-114608; Platelet degranulation.
DR   PRO; PR:Q9I9R0; -.
DR   Proteomes; UP000000539; Chromosome Z.
DR   Bgee; ENSGALG00000012628; Expressed in testis and 14 other tissues.
DR   ExpressionAtlas; Q9I9R0; baseline and differential.
DR   GO; GO:0015030; C:Cajal body; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0010494; C:cytoplasmic stress granule; ISS:UniProtKB.
DR   GO; GO:0097504; C:Gemini of coiled bodies; ISS:UniProtKB.
DR   GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0016528; C:sarcoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0033120; P:positive regulation of RNA splicing; ISS:UniProtKB.
DR   GO; GO:0045948; P:positive regulation of translational initiation; ISS:UniProtKB.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR039764; HABP4/SERBP1.
DR   InterPro; IPR006861; HABP4_PAIRBP1-bd.
DR   InterPro; IPR032381; IHABP4_N.
DR   PANTHER; PTHR12299; PTHR12299; 2.
DR   Pfam; PF04774; HABP4_PAI-RBP1; 1.
DR   Pfam; PF16174; IHABP4_N; 1.
DR   SMART; SM01233; HABP4_PAI-RBP1; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   RNA-binding; Transcription; Transcription regulation;
KW   Translation regulation.
FT   CHAIN           1..357
FT                   /note="Intracellular hyaluronan-binding protein 4"
FT                   /id="PRO_0000257974"
FT   REGION          56..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          150..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          313..357
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..116
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   357 AA;  39968 MW;  C84EEA7CAADDC248 CRC64;
     MMKGAMGCPV AAVMEGSFSC TVANRFYQLL DDESDPFDNL REAERCWQQR KNLSKVVARR
     GDPGSRGCAT RRELQKQRKQ LGTPAPPPQP GQKQAPKQEE CGGKDNSRAE KEHKTAWRPS
     FMEYLSSETE SQAELTAQSL FRPTAKLNYE RPRGCGRGRG GMQGRGRGGG INKSFDGFDQ
     RGKREFGRQN DNDKIEMELT APMEATAKTA KSPGVSEGEL LNKVAEGKPR EEVVQEMTLD
     EWKNLQQQNR PKHEFNIRRP ESTVPSKAVV IHKSKYSDDI QKGELEDDYH IFRRAVNDIT
     FQLDINFGSL PRPGCGSRGA RGRGRGRQME ETGPQPEAMV QIVAPNPDDP EDFPALT