HAF1_ARCFU
ID HAF1_ARCFU Reviewed; 72 AA.
AC O29910;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Probable archaeal histone A1-1;
GN Name=hpyA1-1; OrderedLocusNames=AF_0337;
OS Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS 100126 / VC-16).
OC Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC Archaeoglobus.
OX NCBI_TaxID=224325;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX PubMed=9389475; DOI=10.1038/37052;
RA Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA Smith H.O., Woese C.R., Venter J.C.;
RT "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT archaeon Archaeoglobus fulgidus.";
RL Nature 390:364-370(1997).
CC -!- FUNCTION: Binds and compact DNA (95 to 150 base pairs) to form
CC nucleosome-like structures that contain positive DNA supercoils.
CC Increases the resistance of DNA to thermal denaturation (in vitro).
CC {ECO:0000250|UniProtKB:P19267}.
CC -!- SUBUNIT: Homodimer or heterodimer with another histone. Dimers then
CC assemble into higher oligomers, with the DNA wrapped around the protein
CC core (By similarity). {ECO:0000250|UniProtKB:P19267}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Chromosome
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the archaeal histone HMF family. {ECO:0000305}.
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DR EMBL; AE000782; AAB90902.1; -; Genomic_DNA.
DR PIR; A69292; A69292.
DR RefSeq; WP_010877844.1; NC_000917.1.
DR AlphaFoldDB; O29910; -.
DR SMR; O29910; -.
DR STRING; 224325.AF_0337; -.
DR EnsemblBacteria; AAB90902; AAB90902; AF_0337.
DR GeneID; 24793876; -.
DR KEGG; afu:AF_0337; -.
DR eggNOG; arCOG02144; Archaea.
DR HOGENOM; CLU_192667_0_0_2; -.
DR OMA; ELPVAPC; -.
DR OrthoDB; 127272at2157; -.
DR PhylomeDB; O29910; -.
DR Proteomes; UP000002199; Chromosome.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR003958; CBFA_NFYB_domain.
DR InterPro; IPR009072; Histone-fold.
DR Pfam; PF00808; CBFD_NFYB_HMF; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
PE 3: Inferred from homology;
KW Chromosome; Cytoplasm; DNA-binding; Reference proteome.
FT CHAIN 1..72
FT /note="Probable archaeal histone A1-1"
FT /id="PRO_0000154980"
FT REGION 24..26
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250|UniProtKB:P19267"
FT REGION 58..61
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250|UniProtKB:P19267"
SQ SEQUENCE 72 AA; 7965 MW; 1A9758A85F22E030 CRC64;
MEVLRVELPL APVERLLRKA GASRVSEDAK VELAKAIEEY AMQIGKKAAE LAKHAGRKTV
KVDDIKLALR EL