ID   HAGHL_BOVIN             Reviewed;         193 AA.
AC   Q0VBY3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Hydroxyacylglutathione hydrolase-like protein;
DE            EC=3.1.2.-;
GN   Name=HAGHL;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Basal ganglia;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hydrolase acting on ester bonds. {ECO:0000305}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily.
CC       Glyoxalase II family. {ECO:0000305}.
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DR   EMBL; BC120447; AAI20448.1; -; mRNA.
DR   RefSeq; NP_001069008.2; NM_001075540.2.
DR   AlphaFoldDB; Q0VBY3; -.
DR   SMR; Q0VBY3; -.
DR   STRING; 9913.ENSBTAP00000003220; -.
DR   PaxDb; Q0VBY3; -.
DR   GeneID; 511836; -.
DR   KEGG; bta:511836; -.
DR   CTD; 84264; -.
DR   eggNOG; KOG0813; Eukaryota.
DR   InParanoid; Q0VBY3; -.
DR   OrthoDB; 961826at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0004416; F:hydroxyacylglutathione hydrolase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd07723; hydroxyacylglutathione_hydrolase_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; -; 1.
DR   InterPro; IPR035680; Clx_II_MBL.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; SSF56281; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Metal-binding; Reference proteome; Zinc.
FT   CHAIN           1..193
FT                   /note="Hydroxyacylglutathione hydrolase-like protein"
FT                   /id="PRO_0000313600"
FT   BINDING         54
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         56
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         58
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         59
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         110
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   193 AA;  21696 MW;  5A1A793923DFA19F CRC64;
     MKVKVIPVLE DNYMYLVIEE RTREAVAVDV AVPKRLLEIV GRERVSLTTV LTTHHHWDHA
     RGNAELARLL PGLVVLGADE RICALTRRLA HGEELRFGAI HVRCLLTPGH TLGHMSYFLW
     EEECPDPPAV FSGTGCPVPT CPTSPCPIPL SLTHPTPQGM HCPWPAAAHA WRAQFSRCTR
     AWWRPWAPCP LRQ