ID   HAGHL_CHICK             Reviewed;         282 AA.
AC   Q5ZLY2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Hydroxyacylglutathione hydrolase-like protein;
DE            EC=3.1.2.-;
GN   Name=HAGHL; ORFNames=RCJMB04_21j14, RCJMB04_4h5;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Hydrolase acting on ester bonds. {ECO:0000305}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily.
CC       Glyoxalase II family. {ECO:0000305}.
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DR   EMBL; AJ719602; CAG31261.1; -; mRNA.
DR   EMBL; AJ851726; CAH65360.1; -; mRNA.
DR   RefSeq; NP_001025808.1; NM_001030637.1.
DR   AlphaFoldDB; Q5ZLY2; -.
DR   SMR; Q5ZLY2; -.
DR   STRING; 9031.ENSGALP00000008654; -.
DR   PaxDb; Q5ZLY2; -.
DR   Ensembl; ENSGALT00000008668; ENSGALP00000008654; ENSGALG00000021040.
DR   GeneID; 416536; -.
DR   KEGG; gga:416536; -.
DR   CTD; 84264; -.
DR   VEuPathDB; HostDB:geneid_416536; -.
DR   eggNOG; KOG0813; Eukaryota.
DR   GeneTree; ENSGT00940000161924; -.
DR   HOGENOM; CLU_030571_4_0_1; -.
DR   InParanoid; Q5ZLY2; -.
DR   OMA; CKERARF; -.
DR   OrthoDB; 961826at2759; -.
DR   PhylomeDB; Q5ZLY2; -.
DR   TreeFam; TF105273; -.
DR   PRO; PR:Q5ZLY2; -.
DR   Proteomes; UP000000539; Chromosome 14.
DR   Bgee; ENSGALG00000021040; Expressed in lung and 13 other tissues.
DR   GO; GO:0004416; F:hydroxyacylglutathione hydrolase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019243; P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione; IEA:InterPro.
DR   CDD; cd07723; hydroxyacylglutathione_hydrolase_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; -; 1.
DR   HAMAP; MF_01374; Glyoxalase_2; 1.
DR   InterPro; IPR035680; Clx_II_MBL.
DR   InterPro; IPR032282; HAGH_C.
DR   InterPro; IPR017782; Hydroxyacylglutathione_Hdrlase.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   Pfam; PF16123; HAGH_C; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; SSF56281; 1.
DR   TIGRFAMs; TIGR03413; GSH_gloB; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Metal-binding; Reference proteome; Zinc.
FT   CHAIN           1..282
FT                   /note="Hydroxyacylglutathione hydrolase-like protein"
FT                   /id="PRO_0000313603"
FT   BINDING         54
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         56
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         58
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         59
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         110
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         134
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         134
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         173
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   282 AA;  32228 MW;  C1595401229CFD2E CRC64;
     MKVKVISVLE DNYMYLVIEE STRDAVAVDA AVPKRLLEIV RKEDVVLRAV LITHHHWDHA
     RGNEELVRLC PGLRVYGADE RIGALTHRVA PDEELTFGAI RVRCLFTPCH TKGHMCYFMW
     EDGSLDAPAL FSGDTLFVGG CGQFLEGTAE QMYTNLTQVL GDLPKETKVF CGHECTVRNL
     KFALKVEPEN EAVKKKLAWA RQRDDEDLPT VPSTLQEEFL YNPFLRVTEE AVQKFTGRKE
     PVEVLRALRT EKDNFKKPKE RPHPQAMLAF DWGLFAPFLE KK