ID   AMZ2_MACFA              Reviewed;         360 AA.
AC   Q4R684;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 2.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Archaemetzincin-2;
DE            EC=3.4.-.- {ECO:0000250|UniProtKB:Q8TXW1};
DE   AltName: Full=Archeobacterial metalloproteinase-like protein 2;
GN   Name=AMZ2; ORFNames=QtsA-18820;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable zinc metalloprotease.
CC       {ECO:0000250|UniProtKB:Q8TXW1}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000250|UniProtKB:Q8TXW1};
CC       Note=Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the
CC       other seems to have a structural role. {ECO:0000250|UniProtKB:Q8TXW1};
CC   -!- SIMILARITY: Belongs to the peptidase M54 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE01391.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AB169305; BAE01391.1; ALT_SEQ; mRNA.
DR   AlphaFoldDB; Q4R684; -.
DR   SMR; Q4R684; -.
DR   STRING; 9541.XP_005584824.1; -.
DR   MEROPS; M54.002; -.
DR   eggNOG; ENOG502QVTZ; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd11375; Peptidase_M54; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR012962; Pept_M54_archaemetzincn.
DR   Pfam; PF07998; Peptidase_M54; 1.
DR   PROSITE; PS00142; ZINC_PROTEASE; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome;
KW   Zinc.
FT   CHAIN           1..360
FT                   /note="Archaemetzincin-2"
FT                   /id="PRO_0000159618"
FT   ACT_SITE        255
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT   BINDING         254
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TXW1"
FT   BINDING         258
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TXW1"
FT   BINDING         264
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TXW1"
FT   BINDING         265
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TXW1"
FT   BINDING         270
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TXW1"
FT   BINDING         289
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TXW1"
FT   BINDING         292
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TXW1"
SQ   SEQUENCE   360 AA;  41169 MW;  50A67E01A43C6A3B CRC64;
     MQIIRHSEQT LKTALISKNP VLVSQYEKLD AGEQRLMNEA FQPASDLFGP ITLHSPSDWI
     TSHPEAPQDF EQFFSDPYRK TPSPDKRSVY IQAIGSLGNT RIISEEYIKW LTGYCKAYFY
     GLRVKLLEPV PVSATRCSFR VNENTQNLQI HAGDILKFLK KKKPEDAFCI VGITMIDLYP
     RDSWNFVFGQ ASLTDGVGIF SFARYGSDFY SMRYEGKVKK LKKTSSSDYS IFNNYYIPEI
     TSVLLLRSCK TLTHEIGHIF GLRHCQWLAC LMQGSNHLEE SDRRPLNLCP ICLRKLQCAV
     GFSIVERYKA LVRWIDDESS GTPGATPEHS REGNGNLPKP VEAFKEWKEW IIKCLAVLQK