ID   HAR1_CAEEL              Reviewed;         154 AA.
AC   Q09254;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Hemiasterlin resistant protein 1;
GN   Name=har-1; ORFNames=C16C10.11;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
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DR   EMBL; Z46787; CAA86749.1; -; Genomic_DNA.
DR   PIR; T19332; T19332.
DR   RefSeq; NP_497826.1; NM_065425.3.
DR   AlphaFoldDB; Q09254; -.
DR   STRING; 6239.C16C10.11; -.
DR   EPD; Q09254; -.
DR   PaxDb; Q09254; -.
DR   PeptideAtlas; Q09254; -.
DR   EnsemblMetazoa; C16C10.11.1; C16C10.11.1; WBGene00007630.
DR   GeneID; 175529; -.
DR   KEGG; cel:CELE_C16C10.11; -.
DR   UCSC; C16C10.11.1; c. elegans.
DR   CTD; 175529; -.
DR   WormBase; C16C10.11; CE01491; WBGene00007630; har-1.
DR   eggNOG; KOG4090; Eukaryota.
DR   GeneTree; ENSGT00940000172340; -.
DR   HOGENOM; CLU_093520_2_1_1; -.
DR   InParanoid; Q09254; -.
DR   OMA; CKYSHGV; -.
DR   OrthoDB; 1611117at2759; -.
DR   PhylomeDB; Q09254; -.
DR   PRO; PR:Q09254; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00007630; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; HDA:WormBase.
DR   GO; GO:0005739; C:mitochondrion; HDA:WormBase.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0055120; C:striated muscle dense body; HDA:WormBase.
DR   GO; GO:0008340; P:determination of adult lifespan; IMP:UniProtKB.
DR   GO; GO:0007005; P:mitochondrion organization; IGI:UniProtKB.
DR   InterPro; IPR010625; CHCH.
DR   Pfam; PF06747; CHCH; 1.
DR   PROSITE; PS51808; CHCH; 1.
PE   4: Predicted;
KW   Disulfide bond; Reference proteome.
FT   CHAIN           1..154
FT                   /note="Hemiasterlin resistant protein 1"
FT                   /id="PRO_0000065185"
FT   DOMAIN          116..154
FT                   /note="CHCH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   REGION          1..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          86..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           119..129
FT                   /note="Cx9C motif 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   MOTIF           139..149
FT                   /note="Cx9C motif 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   COMPBIAS        25..51
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        119..149
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   DISULFID        129..139
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ   SEQUENCE   154 AA;  15388 MW;  5F5C618B637D2683 CRC64;
     MVRRRTASPS PSAPVRSAPR PAAQSSFAAP PPRPAAAAPA YHPPAAPTPM GAPMGAPSQG
     PGLMKQMAAT AGGVAIGSAV GHAVGGMFTG GGSSHAEQAP AAAAAPAGAP QASGYSQPCE
     FEWRQFVDCA QNQSDVSLCN GFNDIFKQCK ARYA