ID   HARB_PYRSG              Reviewed;          67 AA.
AC   P50486;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Archaeal histone B;
DE   AltName: Full=Archaeal histone A2;
GN   Name=hpyA2;
OS   Pyrococcus sp. (strain GB-3a).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus; unclassified Pyrococcus.
OX   NCBI_TaxID=55399;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7959058; DOI=10.1016/0378-1119(94)90890-7;
RA   Sandman K.M., Perler F.B., Reeve J.N.;
RT   "Histone-encoding genes from Pyrococcus: evidence for members of the HMf
RT   family of archaeal histones in a non-methanogenic Archaeon.";
RL   Gene 150:207-208(1994).
CC   -!- FUNCTION: Binds and compact DNA (95 to 150 base pairs) to form
CC       nucleosome-like structures that contain positive DNA supercoils.
CC       Increases the resistance of DNA to thermal denaturation (in vitro).
CC       {ECO:0000250|UniProtKB:P19267}.
CC   -!- SUBUNIT: Homodimer or heterodimer with another histone. Dimers then
CC       assemble into higher oligomers, with the DNA wrapped around the protein
CC       core (By similarity). {ECO:0000250|UniProtKB:P19267}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Chromosome
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the archaeal histone HMF family. {ECO:0000305}.
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DR   EMBL; U08838; AAA73427.1; -; Genomic_DNA.
DR   AlphaFoldDB; P50486; -.
DR   SMR; P50486; -.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR003958; CBFA_NFYB_domain.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR004823; TAF_TATA-bd_Histone-like_dom.
DR   Pfam; PF00808; CBFD_NFYB_HMF; 1.
DR   SMART; SM00803; TAF; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
PE   3: Inferred from homology;
KW   Chromosome; Cytoplasm; DNA-binding.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..67
FT                   /note="Archaeal histone B"
FT                   /id="PRO_0000155003"
FT   REGION          20..22
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250|UniProtKB:P19267"
FT   REGION          54..57
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250|UniProtKB:P19267"
SQ   SEQUENCE   67 AA;  7338 MW;  00B2C1D3635C374A CRC64;
     MAELPIAPVD RLIRKAGAQR VSEQAAKLLA EHLEEKALEI ARKAVDLAKH AGRKTVKAED
     IKLAIRS