HAT12_DICDI
ID HAT12_DICDI Reviewed; 466 AA.
AC Q869X7; Q553Z3;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Histone acetyltransferase type B catalytic subunit DDB_G0275159;
DE EC=2.3.1.48 {ECO:0000250|UniProtKB:O14929};
GN ORFNames=DDB_G0275159;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-
CC lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752,
CC Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48;
CC Evidence={ECO:0000250|UniProtKB:O14929};
CC -!- SIMILARITY: Belongs to the HAT1 family. {ECO:0000305}.
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DR EMBL; AAFI02000013; EAL69860.1; -; Genomic_DNA.
DR RefSeq; XP_643818.1; XM_638726.1.
DR AlphaFoldDB; Q869X7; -.
DR SMR; Q869X7; -.
DR STRING; 44689.DDB0237833; -.
DR PaxDb; Q869X7; -.
DR PRIDE; Q869X7; -.
DR EnsemblProtists; EAL69860; EAL69860; DDB_G0275159.
DR GeneID; 8619865; -.
DR KEGG; ddi:DDB_G0275159; -.
DR dictyBase; DDB_G0275159; -.
DR eggNOG; KOG2696; Eukaryota.
DR HOGENOM; CLU_036024_2_1_1; -.
DR InParanoid; Q869X7; -.
DR OMA; YFINLDE; -.
DR PhylomeDB; Q869X7; -.
DR PRO; PR:Q869X7; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:GOC.
DR GO; GO:0000123; C:histone acetyltransferase complex; ISS:dictyBase.
DR GO; GO:0010485; F:H4 histone acetyltransferase activity; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; ISS:dictyBase.
DR GO; GO:0016573; P:histone acetylation; ISS:dictyBase.
DR GO; GO:0043967; P:histone H4 acetylation; IBA:GO_Central.
DR GO; GO:0031509; P:subtelomeric heterochromatin assembly; IEA:InterPro.
DR Gene3D; 3.90.360.10; -; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR019467; Hat1_N.
DR InterPro; IPR037113; Hat1_N_sf.
DR InterPro; IPR017380; Hist_AcTrfase_B-typ_cat-su.
DR PANTHER; PTHR12046; PTHR12046; 1.
DR Pfam; PF10394; Hat1_N; 1.
DR PIRSF; PIRSF038084; HAT-B_cat; 1.
DR SUPFAM; SSF55729; SSF55729; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Coiled coil; Reference proteome; Transferase.
FT CHAIN 1..466
FT /note="Histone acetyltransferase type B catalytic subunit
FT DDB_G0275159"
FT /id="PRO_0000367832"
FT DOMAIN 169..366
FT /note="N-acetyltransferase"
FT COILED 372..459
FT /evidence="ECO:0000255"
FT ACT_SITE 279
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000250|UniProtKB:O14929"
FT BINDING 240..242
FT /ligand="acetyl-CoA"
FT /ligand_id="ChEBI:CHEBI:57288"
FT /evidence="ECO:0000250|UniProtKB:O14929"
FT BINDING 247..253
FT /ligand="acetyl-CoA"
FT /ligand_id="ChEBI:CHEBI:57288"
FT /evidence="ECO:0000250|UniProtKB:O14929"
FT SITE 198
FT /note="Interaction with histone H4 N-terminus"
FT /evidence="ECO:0000250|UniProtKB:O14929"
SQ SEQUENCE 466 AA; 55013 MW; 16FDB57EB0E4565B CRC64;
MTSKIKSSNT LLTFDANEVT NIKLVWDIEE LKNKDKEDKA HIKDEEEDED GPVSFHPSFS
HQIFNDEQVQ GYEACKIDIY MGAGSLTSYI DTNYTLQSKN LTNVEGELLK VFSKQDPPIS
KQSFYKFIEE KEKSFKPIGK KIHEYTITDK ESGEETEYEV YFGRITDQAV FRYHEKLQIF
VLWYIDGSSY IWTDDPNWDI FFIFEKRIID GEKRYGITGY STIYNFYHHP EQTRARISQY
LILPPYQRMG HGKYLFNSIH QYYKTNDGFY GPVYDVTIED PADDFNLLRN YVDLKNIIDE
KLFDNVILDL NANNKSVFEE IRKKLLVPHK QSKVCLEIYL FSKFLATPNS NPKYKEFRIA
IKKRLYKQNI GDSEQIEKMK QQVAQENEDN LRLEQEELQE LQDIENKKNG TNIKVAINTK
ELTTPSEPEK SKEEIEKDRL EEIIQLYKDL EENYHKTLSS LNLITK
