HAT2_ARATH
ID HAT2_ARATH Reviewed; 283 AA.
AC P46601; Q546H4; Q9LVS2;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 25-MAY-2022, entry version 162.
DE RecName: Full=Homeobox-leucine zipper protein HAT2;
DE AltName: Full=Homeodomain-leucine zipper protein HAT2;
DE Short=HD-ZIP protein 2;
GN Name=HAT2; OrderedLocusNames=At5g47370; ORFNames=MQL5.23;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, AND FUNCTION.
RX PubMed=12492842; DOI=10.1046/j.1365-313x.2002.01488.x;
RA Sawa S., Ohgishi M., Goda H., Higuchi K., Shimada Y., Yoshida S.,
RA Koshiba T.;
RT "The HAT2 gene, a member of the HD-Zip gene family, isolated as an auxin
RT inducible gene by DNA microarray screening, affects auxin response in
RT Arabidopsis.";
RL Plant J. 32:1011-1022(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RA Carabelli M., Ciarbelli A.R., Ruzza V., Sessa G., Steindler C., Ruberti I.;
RT "Nucleotide sequence of the Arabidopsis HAT2 mRNA, encoding an HD-Zip II
RT protein related to ATHB-2.";
RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 76-283.
RC STRAIN=cv. Columbia;
RX PubMed=7915839; DOI=10.1073/pnas.91.18.8393;
RA Schena M., Davis R.W.;
RT "Structure of homeobox-leucine zipper genes suggests a model for the
RT evolution of gene families.";
RL Proc. Natl. Acad. Sci. U.S.A. 91:8393-8397(1994).
RN [7]
RP GENE FAMILY.
RX PubMed=16055682; DOI=10.1104/pp.105.063461;
RA Henriksson E., Olsson A.S.B., Johannesson H., Johansson H., Hanson J.,
RA Engstroem P., Soederman E.;
RT "Homeodomain leucine zipper class I genes in Arabidopsis. Expression
RT patterns and phylogenetic relationships.";
RL Plant Physiol. 139:509-518(2005).
RN [8]
RP INTERACTION WITH RBR1.
RX PubMed=24302889; DOI=10.1371/journal.pbio.1001724;
RA Cruz-Ramirez A., Diaz-Trivino S., Wachsman G., Du Y., Arteaga-Vazquez M.,
RA Zhang H., Benjamins R., Blilou I., Neef A.B., Chandler V., Scheres B.;
RT "A SCARECROW-RETINOBLASTOMA protein network controls protective quiescence
RT in the Arabidopsis root stem cell organizer.";
RL PLoS Biol. 11:E1001724-E1001724(2013).
CC -!- FUNCTION: Probable transcription factor that plays a role in auxin-
CC mediated morphogenesis. Negatively regulates lateral root elongation.
CC {ECO:0000269|PubMed:12492842}.
CC -!- SUBUNIT: Interacts with RBR1. {ECO:0000269|PubMed:24302889}.
CC -!- INTERACTION:
CC P46601; Q8GXM7: ATHB-X; NbExp=5; IntAct=EBI-4448195, EBI-3133795;
CC P46601; P46602: HAT3; NbExp=3; IntAct=EBI-4448195, EBI-4450405;
CC P46601; Q05466: HAT4; NbExp=4; IntAct=EBI-4448195, EBI-4428728;
CC P46601; Q9S7W5: TCP13; NbExp=5; IntAct=EBI-4448195, EBI-4424877;
CC P46601; Q8LPR5: TCP4; NbExp=3; IntAct=EBI-4448195, EBI-15192325;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- INDUCTION: By indole-3-acetic acid (IAA).
CC {ECO:0000269|PubMed:12492842}.
CC -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class II subfamily.
CC {ECO:0000305}.
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DR EMBL; AB067629; BAB63202.1; -; mRNA.
DR EMBL; AJ431183; CAD24013.1; -; mRNA.
DR EMBL; AB018117; BAA97171.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95503.1; -; Genomic_DNA.
DR EMBL; AF428450; AAL16219.1; -; mRNA.
DR EMBL; AY052324; AAK96517.1; -; mRNA.
DR EMBL; AY061904; AAL31231.1; -; mRNA.
DR EMBL; U09335; AAA56901.1; -; mRNA.
DR PIR; T52368; T52368.
DR RefSeq; NP_199548.1; NM_124108.3.
DR AlphaFoldDB; P46601; -.
DR SMR; P46601; -.
DR BioGRID; 20032; 30.
DR DIP; DIP-60613N; -.
DR IntAct; P46601; 26.
DR STRING; 3702.AT5G47370.1; -.
DR iPTMnet; P46601; -.
DR PaxDb; P46601; -.
DR PRIDE; P46601; -.
DR ProteomicsDB; 230305; -.
DR EnsemblPlants; AT5G47370.1; AT5G47370.1; AT5G47370.
DR GeneID; 834784; -.
DR Gramene; AT5G47370.1; AT5G47370.1; AT5G47370.
DR KEGG; ath:AT5G47370; -.
DR Araport; AT5G47370; -.
DR TAIR; locus:2171489; AT5G47370.
DR eggNOG; KOG0483; Eukaryota.
DR HOGENOM; CLU_049516_2_1_1; -.
DR InParanoid; P46601; -.
DR OMA; CTEENEM; -.
DR OrthoDB; 1388148at2759; -.
DR PhylomeDB; P46601; -.
DR PRO; PR:P46601; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; P46601; baseline and differential.
DR Genevisible; P46601; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; ISS:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0009734; P:auxin-activated signaling pathway; IEP:TAIR.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:TAIR.
DR GO; GO:0009733; P:response to auxin; IMP:TAIR.
DR GO; GO:0009641; P:shade avoidance; IEP:TAIR.
DR GO; GO:0009826; P:unidimensional cell growth; IMP:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR006712; HD-ZIP_N.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003106; Leu_zip_homeo.
DR Pfam; PF02183; HALZ; 1.
DR Pfam; PF04618; HD-ZIP_N; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00340; HALZ; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..283
FT /note="Homeobox-leucine zipper protein HAT2"
FT /id="PRO_0000048899"
FT DNA_BIND 127..186
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 64..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..215
FT /note="Leucine-zipper"
FT COMPBIAS 64..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 283 AA; 31727 MW; BA594B82B9D85E64 CRC64;
MMMGKEDLGL SLSLGFSQNH NPLQMNLNPN SSLSNNLQRL PWNQTFDPTS DLRKIDVNSF
PSTVNCEEDT GVSSPNSTIS STISGKRSER EGISGTGVGS GDDHDEITPD RGYSRGTSDE
EEDGGETSRK KLRLSKDQSA FLEETFKEHN TLNPKQKLAL AKKLNLTARQ VEVWFQNRRA
RTKLKQTEVD CEYLKRCVEK LTEENRRLQK EAMELRTLKL SPQFYGQMTP PTTLIMCPSC
ERVGGPSSSN HHHNHRPVSI NPWVACAGQV AHGLNFEALR PRS
