ID   HAT2_ASPFU              Reviewed;         436 AA.
AC   Q4WEI5;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Histone acetyltransferase type B subunit 2;
GN   Name=hat2; ORFNames=AFUA_5G03130;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Regulatory subunit of the histone acetylase B (HAT-B)
CC       complex. The complex acetylates 'Lys-12' of histone H4 which is
CC       required for telomeric silencing. {ECO:0000250|UniProtKB:P39984}.
CC   -!- SUBUNIT: Component of the HAT-B complex composed of at least hat1 and
CC       hat2. The HAT-B complex binds to histone H4 tail.
CC       {ECO:0000250|UniProtKB:P39984}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAHF01000011; EAL85992.1; -; Genomic_DNA.
DR   RefSeq; XP_748030.1; XM_742937.1.
DR   AlphaFoldDB; Q4WEI5; -.
DR   SMR; Q4WEI5; -.
DR   STRING; 746128.CADAFUBP00005055; -.
DR   EnsemblFungi; EAL85992; EAL85992; AFUA_5G03130.
DR   GeneID; 3505380; -.
DR   KEGG; afm:AFUA_5G03130; -.
DR   VEuPathDB; FungiDB:Afu5g03130; -.
DR   eggNOG; KOG0264; Eukaryota.
DR   HOGENOM; CLU_020445_3_1_1; -.
DR   InParanoid; Q4WEI5; -.
DR   OMA; PHEEGCL; -.
DR   OrthoDB; 831322at2759; -.
DR   Proteomes; UP000002530; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; IBA:GO_Central.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR022052; Histone-bd_RBBP4_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12265; CAF1C_H4-bd; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Cytoplasm; Nucleus; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..436
FT                   /note="Histone acetyltransferase type B subunit 2"
FT                   /id="PRO_0000227733"
FT   REPEAT          136..176
FT                   /note="WD 1"
FT   REPEAT          187..227
FT                   /note="WD 2"
FT   REPEAT          237..277
FT                   /note="WD 3"
FT   REPEAT          284..324
FT                   /note="WD 4"
FT   REPEAT          328..368
FT                   /note="WD 5"
FT   REPEAT          385..425
FT                   /note="WD 6"
FT   REGION          370..374
FT                   /note="Interaction with the histone H4 N-terminus"
FT                   /evidence="ECO:0000250|UniProtKB:P39984"
SQ   SEQUENCE   436 AA;  48951 MW;  C7E7AC9CA61BD6CE CRC64;
     MEPYDDAVVE EHEEQEEERT EEKIINEEYK TWKKNAPFLY DMILSTALEW PTLTTQWLPD
     KQEVPDKPYS THRLLIGTHT SSDAQNYLQI AHVQLPNPSA PNPDDYDEER GEIGGYGGSS
     KKAPMEIKFN IVQKIDHKGE VNKARYQPQN PNIIATMCTD GRVMVWDRSK HPSLPTGQVN
     PQMELIGHTK EGFGLSWSPH TAGQLATGSE DKTVRIWDLT TYSKGNKLLK PSRTYTHHSS
     IVNDVQYHPL HSSLIGTVSD DITLQILDIR ESETTRAAAS TEGQHRDAIN AIAFNPAAET
     VLATGSADKT IGLWDLRNLK TKLHSLESHT DSVTSISWHP FEEAVLASAS YDRKIAFWDL
     SRAGEEQTPE DAQDGPPELL FQHGGHTNRI SDFSWNLNDP WVLCSAAEDN LLQVWKVADA
     IVGKDLEDVP TEELEP