ID   HAT2_CRYNB              Reviewed;         435 AA.
AC   P0CS37; Q55PL6; Q5KDT9;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Histone acetyltransferase type B subunit 2;
GN   Name=HAT2; OrderedLocusNames=CNBG1970;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Regulatory subunit of the histone acetylase B (HAT-B)
CC       complex. The complex acetylates 'Lys-12' of histone H4 which is
CC       required for telomeric silencing. {ECO:0000250|UniProtKB:P39984}.
CC   -!- SUBUNIT: Component of the HAT-B complex composed of at least HAT1 and
CC       HAT2. The HAT-B complex binds to histone H4 tail.
CC       {ECO:0000250|UniProtKB:P39984}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
CC       {ECO:0000305}.
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DR   EMBL; AAEY01000038; EAL19568.1; -; Genomic_DNA.
DR   RefSeq; XP_774215.1; XM_769122.1.
DR   AlphaFoldDB; P0CS37; -.
DR   SMR; P0CS37; -.
DR   EnsemblFungi; AAW44637; AAW44637; CNG02800.
DR   EnsemblFungi; EAL19568; EAL19568; CNBG1970.
DR   GeneID; 4937231; -.
DR   KEGG; cnb:CNBG1970; -.
DR   VEuPathDB; FungiDB:CNBG1970; -.
DR   HOGENOM; CLU_020445_3_1_1; -.
DR   Proteomes; UP000001435; Chromosome 7.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR022052; Histone-bd_RBBP4_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12265; CAF1C_H4-bd; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Cytoplasm; Nucleus; Repeat; WD repeat.
FT   CHAIN           1..435
FT                   /note="Histone acetyltransferase type B subunit 2"
FT                   /id="PRO_0000410331"
FT   REPEAT          135..175
FT                   /note="WD 1"
FT   REPEAT          188..228
FT                   /note="WD 2"
FT   REPEAT          238..278
FT                   /note="WD 3"
FT   REPEAT          284..324
FT                   /note="WD 4"
FT   REPEAT          328..368
FT                   /note="WD 5"
FT   REPEAT          385..425
FT                   /note="WD 6"
FT   REGION          370..374
FT                   /note="Interaction with the histone H4 N-terminus"
FT                   /evidence="ECO:0000250|UniProtKB:P39984"
FT   SITE            301
FT                   /note="Important for interaction with HAT1"
FT                   /evidence="ECO:0000250|UniProtKB:P39984"
SQ   SEQUENCE   435 AA;  48478 MW;  A47BC4BAD7F12AB9 CRC64;
     MAHNEPITID DAGDDFDAVE DNQAINEQYK VWKKNTPFLY DTVITHALTW PSLTCQWLPD
     ITDVPDTDYT SQRLIIGTHT SGQANDHLII AEVLLPKKGA GISDKALADL YDEEKQEIGS
     YTASPARIRA IQTINHAGEV NRARYMPQNP ELIATKTVTG EVYVFDRTKH ESKAPANGEC
     KPDIRLKGQT KEGYGLSWNA LKEGHILSAS EDTTIGHWDI QGYSKQDPSL QPLRLYTGHS
     AYVADVEWHP KNENMFGSVS DDGQIMIWDT RSDNTAKASS QVQGHNAEIN CISFAPSSEY
     LFLTGSSDNT IALWDLRKLS TKHHSFEAHT NDVLQLSWSP TSPVHFASAS ADRRVHIWDL
     DAIGAEQTPD DAEDGPPELL FVHGGHTSKV CDISWSPSSP WTIASASEDN ILQVWEPSRH
     LRTPYEAEFD EKDLE