HAT2_CRYNJ
ID HAT2_CRYNJ Reviewed; 435 AA.
AC P0CS36; Q55PL6; Q5KDT9;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 51.
DE RecName: Full=Histone acetyltransferase type B subunit 2;
GN Name=HAT2; OrderedLocusNames=CNG02800;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Regulatory subunit of the histone acetylase B (HAT-B)
CC complex. The complex acetylates 'Lys-12' of histone H4 which is
CC required for telomeric silencing. {ECO:0000250|UniProtKB:P39984}.
CC -!- SUBUNIT: Component of the HAT-B complex composed of at least HAT1 and
CC HAT2. The HAT-B complex binds to histone H4 tail.
CC {ECO:0000250|UniProtKB:P39984}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
CC {ECO:0000305}.
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DR EMBL; AE017347; AAW44637.1; -; Genomic_DNA.
DR RefSeq; XP_571944.1; XM_571944.1.
DR AlphaFoldDB; P0CS36; -.
DR SMR; P0CS36; -.
DR STRING; 5207.AAW44637; -.
DR PaxDb; P0CS36; -.
DR EnsemblFungi; AAW44637; AAW44637; CNG02800.
DR GeneID; 3258762; -.
DR KEGG; cne:CNG02800; -.
DR VEuPathDB; FungiDB:CNG02800; -.
DR eggNOG; KOG0264; Eukaryota.
DR HOGENOM; CLU_020445_3_1_1; -.
DR InParanoid; P0CS36; -.
DR OMA; PHEEGCL; -.
DR OrthoDB; 831322at2759; -.
DR Proteomes; UP000002149; Chromosome 7.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0033698; C:Rpd3L complex; IBA:GO_Central.
DR GO; GO:0070210; C:Rpd3L-Expanded complex; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR022052; Histone-bd_RBBP4_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF12265; CAF1C_H4-bd; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Chromatin regulator; Cytoplasm; Nucleus; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1..435
FT /note="Histone acetyltransferase type B subunit 2"
FT /id="PRO_0000227737"
FT REPEAT 135..175
FT /note="WD 1"
FT REPEAT 188..228
FT /note="WD 2"
FT REPEAT 238..278
FT /note="WD 3"
FT REPEAT 284..324
FT /note="WD 4"
FT REPEAT 328..368
FT /note="WD 5"
FT REPEAT 385..425
FT /note="WD 6"
FT REGION 370..374
FT /note="Interaction with the histone H4 N-terminus"
FT /evidence="ECO:0000250|UniProtKB:P39984"
FT SITE 301
FT /note="Important for interaction with HAT1"
FT /evidence="ECO:0000250|UniProtKB:P39984"
SQ SEQUENCE 435 AA; 48478 MW; A47BC4BAD7F12AB9 CRC64;
MAHNEPITID DAGDDFDAVE DNQAINEQYK VWKKNTPFLY DTVITHALTW PSLTCQWLPD
ITDVPDTDYT SQRLIIGTHT SGQANDHLII AEVLLPKKGA GISDKALADL YDEEKQEIGS
YTASPARIRA IQTINHAGEV NRARYMPQNP ELIATKTVTG EVYVFDRTKH ESKAPANGEC
KPDIRLKGQT KEGYGLSWNA LKEGHILSAS EDTTIGHWDI QGYSKQDPSL QPLRLYTGHS
AYVADVEWHP KNENMFGSVS DDGQIMIWDT RSDNTAKASS QVQGHNAEIN CISFAPSSEY
LFLTGSSDNT IALWDLRKLS TKHHSFEAHT NDVLQLSWSP TSPVHFASAS ADRRVHIWDL
DAIGAEQTPD DAEDGPPELL FVHGGHTSKV CDISWSPSSP WTIASASEDN ILQVWEPSRH
LRTPYEAEFD EKDLE
