ID   HAT2_ENCCU              Reviewed;         384 AA.
AC   Q8SRK1;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Histone acetyltransferase type B subunit 2;
GN   Name=HAT2; OrderedLocusNames=ECU07_0750;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], AND
RP   DEVELOPMENTAL STAGE.
RX   PubMed=16691553; DOI=10.1002/pmic.200500796;
RA   Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.;
RT   "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi
RT   (microsporidia): a reference map for proteins expressed in late sporogonial
RT   stages.";
RL   Proteomics 6:3625-3635(2006).
CC   -!- FUNCTION: Regulatory subunit of the histone acetylase B (HAT-B)
CC       complex. The complex acetylates histone H4 which is required for
CC       telomeric silencing (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the HAT-B complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in late sporogonial stages.
CC       {ECO:0000269|PubMed:16691553}.
CC   -!- SIMILARITY: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
CC       {ECO:0000305}.
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DR   EMBL; AL590447; CAD25607.1; -; Genomic_DNA.
DR   RefSeq; NP_586003.1; NM_001041625.1.
DR   AlphaFoldDB; Q8SRK1; -.
DR   SMR; Q8SRK1; -.
DR   STRING; 284813.Q8SRK1; -.
DR   GeneID; 859432; -.
DR   KEGG; ecu:ECU07_0750; -.
DR   VEuPathDB; MicrosporidiaDB:ECU07_0750; -.
DR   HOGENOM; CLU_020445_3_1_1; -.
DR   InParanoid; Q8SRK1; -.
DR   OMA; PITDFNW; -.
DR   OrthoDB; 831322at2759; -.
DR   Proteomes; UP000000819; Chromosome VII.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR022052; Histone-bd_RBBP4_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12265; CAF1C_H4-bd; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Chromatin regulator; Cytoplasm; Nucleus; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..384
FT                   /note="Histone acetyltransferase type B subunit 2"
FT                   /id="PRO_0000383030"
FT   REPEAT          156..196
FT                   /note="WD 1"
FT   REPEAT          203..243
FT                   /note="WD 2"
FT   REPEAT          247..287
FT                   /note="WD 3"
FT   REPEAT          291..331
FT                   /note="WD 4"
FT   REPEAT          348..384
FT                   /note="WD 5"
SQ   SEQUENCE   384 AA;  43089 MW;  D27B512FCFA41D07 CRC64;
     MDNQVLEQKI VNEEYKIWKK NVPYLYDLMF SHTLEWPSLS VQWFPDVRRD EEAGRTTQRL
     LLSTHTSGSE EEYILIAKVE FPDEFDESLN EEVGGDMRLK IIQRISIMDE ANRVRYNPSA
     CNVLAVRSDL PDIHVYDYTK HLSHEKIPRP DMVLRGHSAG GFGLSWNHLN PGELAGCGEG
     GEVCVFDVSQ ESSSISPTVV LRRHETAVND CAFSFFDKKL LSSAGDGGMV VLWDTRSEDC
     IHAIEEAHTS DILSVRFSPL DGNVIATSSC DGSVKVWDRR SLSQPLHILL GHSKDVVSVE
     WSPHNDKVLA SGSTDRRVIV WDLGQAGAEV PEEYKAEGPP EMKFLHGGHT STVCDISWNP
     AEPFEIASVS EDNILQIWQM PQPE