ID   HAT2_KLULA              Reviewed;         408 AA.
AC   Q6CSI1;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Histone acetyltransferase type B subunit 2;
GN   Name=HAT2; OrderedLocusNames=KLLA0D00814g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Regulatory subunit of the histone acetylase B (HAT-B)
CC       complex. The complex acetylates 'Lys-12' of histone H4 which is
CC       required for telomeric silencing. {ECO:0000250|UniProtKB:P39984}.
CC   -!- SUBUNIT: Component of the HAT-B complex composed of at least HAT1 and
CC       HAT2. The HAT-B complex binds to histone H4 tail.
CC       {ECO:0000250|UniProtKB:P39984}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
CC       {ECO:0000305}.
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DR   EMBL; CR382124; CAH00204.1; -; Genomic_DNA.
DR   RefSeq; XP_453108.1; XM_453108.1.
DR   AlphaFoldDB; Q6CSI1; -.
DR   SMR; Q6CSI1; -.
DR   STRING; 28985.XP_453108.1; -.
DR   EnsemblFungi; CAH00204; CAH00204; KLLA0_D00814g.
DR   GeneID; 2892824; -.
DR   KEGG; kla:KLLA0_D00814g; -.
DR   eggNOG; KOG0264; Eukaryota.
DR   HOGENOM; CLU_020445_3_1_1; -.
DR   InParanoid; Q6CSI1; -.
DR   OMA; PHEEGCL; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:GOC.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000123; C:histone acetyltransferase complex; IEA:EnsemblFungi.
DR   GO; GO:0004402; F:histone acetyltransferase activity; IEA:EnsemblFungi.
DR   GO; GO:0042393; F:histone binding; IEA:EnsemblFungi.
DR   GO; GO:0031509; P:subtelomeric heterochromatin assembly; IEA:EnsemblFungi.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR022052; Histone-bd_RBBP4_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12265; CAF1C_H4-bd; 1.
DR   Pfam; PF00400; WD40; 2.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Cytoplasm; Nucleus; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..408
FT                   /note="Histone acetyltransferase type B subunit 2"
FT                   /id="PRO_0000227741"
FT   REPEAT          120..160
FT                   /note="WD 1"
FT   REPEAT          167..207
FT                   /note="WD 2"
FT   REPEAT          213..253
FT                   /note="WD 3"
FT   REPEAT          255..295
FT                   /note="WD 4"
FT   REPEAT          299..339
FT                   /note="WD 5"
FT   REPEAT          356..396
FT                   /note="WD 6"
FT   REGION          341..345
FT                   /note="Interaction with the histone H4 N-terminus"
FT                   /evidence="ECO:0000250|UniProtKB:P39984"
FT   SITE            272
FT                   /note="Important for interaction with HAT1"
FT                   /evidence="ECO:0000250|UniProtKB:P39984"
SQ   SEQUENCE   408 AA;  45957 MW;  35509D1B91F3F7AF CRC64;
     MTEVEEPEQP TTINEEYDLW VSNVPMMYDF VSETRLTWPS LTVQWLPTEM QPREVDGQQL
     LRQELLIGTL TTDNEPNYLK IAAIDLPENV TSSKPSVSDD AKENELSHRQ SKIKIVRKFK
     HEQEVTRARY MPQSPNIIAT LNGAGIVYIF DRNIKEKDHG AIASFSYHKE NGYGLAFNPT
     VSGQLLSASD DGTVALWDVT STANKSPSQT FDVHTDIVND CKWHEFQSSL FGTVSEDNTL
     IIHDTNSDRA IQKLSVSSAF NTLAFSKRSE NLLAAAGTDS NVYLYDLRRL QKPLHSMAGH
     EDSVTSLEFS PHQDGLLTSS GSDRRIIMWD LFNIGAEQQP DDAYDGVPEL FMMHGGHRSP
     VNEFSHNSNV PWLMCSVEEE NVLQIWKPAN KIVRPPQPPA DFDITTLE