ID   HATC_DICDI              Reviewed;         119 AA.
AC   Q54DM0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Hisactophilin-3;
DE   AltName: Full=Histidine-rich actin-binding protein 3;
GN   Name=hatC; ORFNames=DDB_G0292136;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May act as an intracellular pH sensor that links chemotactic
CC       signals to responses in the microfilament system of the cells by
CC       nucleating actin polymerization or stabilizing the filaments.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Cell membrane {ECO:0000250}; Lipid-
CC       anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- PTM: Phosphorylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the hisactophilin family. {ECO:0000305}.
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DR   EMBL; AAFI02000187; EAL61424.1; -; Genomic_DNA.
DR   RefSeq; XP_629852.1; XM_629850.1.
DR   AlphaFoldDB; Q54DM0; -.
DR   SMR; Q54DM0; -.
DR   STRING; 44689.DDB0232313; -.
DR   PaxDb; Q54DM0; -.
DR   EnsemblProtists; EAL61424; EAL61424; DDB_G0292136.
DR   GeneID; 8628532; -.
DR   KEGG; ddi:DDB_G0292136; -.
DR   dictyBase; DDB_G0292136; hatC.
DR   HOGENOM; CLU_2077490_0_0_1; -.
DR   PhylomeDB; Q54DM0; -.
DR   PRO; PR:Q54DM0; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005829; C:cytosol; ISS:dictyBase.
DR   GO; GO:0005886; C:plasma membrane; ISS:dictyBase.
DR   GO; GO:0051015; F:actin filament binding; ISS:dictyBase.
DR   GO; GO:0005504; F:fatty acid binding; ISS:dictyBase.
DR   InterPro; IPR008999; Actin-crosslinking.
DR   SUPFAM; SSF50405; SSF50405; 1.
PE   3: Inferred from homology;
KW   Actin-binding; Cell membrane; Cytoplasm; Lipoprotein; Membrane; Myristate;
KW   Phosphoprotein; Reference proteome; Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..119
FT                   /note="Hisactophilin-3"
FT                   /id="PRO_0000319629"
FT   REPEAT          34..47
FT                   /note="1"
FT   REPEAT          75..87
FT                   /note="2"
FT   REGION          8..110
FT                   /note="Contains several HHXH repeats"
FT   REGION          34..87
FT                   /note="2 X 13 AA approximate repeats"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   119 AA;  13867 MW;  DEF30AB06C0FC3F5 CRC64;
     MGNRAFKSHH GHFLSAEDCK VKTHHGHHDH HTHFHVENHG HHKVAIRTHA NKYVSINDNN
     DVYISHHFHG EHSLFHLEHH GGKVSIKGHN HYYIAADQHG SIYTTHHHHH DATFEEFIV