ID   HAUS1_BOVIN             Reviewed;         278 AA.
AC   Q2TBK4;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=HAUS augmin-like complex subunit 1;
DE   AltName: Full=Coiled-coil domain-containing protein 5;
GN   Name=HAUS1; Synonyms=CCDC5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Contributes to mitotic spindle assembly, maintenance of
CC       centrosome integrity and completion of cytokinesis as part of the HAUS
CC       augmin-like complex. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the HAUS augmin-like complex. The complex
CC       interacts with the gamma-tubulin ring complex and this interaction is
CC       required for spindle assembly. Associates with microtubules. The
CC       interaction with microtubules is strong during mitosis, while it is
CC       weak or absent during interphase. It is unclear whether this
CC       interaction is direct or indirect (By similarity). Interacts with EML3
CC       (phosphorylated form) (By similarity). {ECO:0000250|UniProtKB:Q96CS2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96CS2}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC       {ECO:0000250|UniProtKB:Q96CS2}. Cytoplasm, cytoskeleton, spindle
CC       {ECO:0000250|UniProtKB:Q96CS2}. Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000250|UniProtKB:Q96CS2}. Note=Localizes with the spindle poles
CC       in mitotic cells. In interphase, localized at the centrosome and
CC       diffusely in the cytoplasm. Localizes to mitotic spindle microtubules
CC       (By similarity). {ECO:0000250|UniProtKB:Q96CS2}.
CC   -!- SIMILARITY: Belongs to the HAUS1 family. {ECO:0000305}.
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DR   EMBL; BC110011; AAI10012.1; -; mRNA.
DR   RefSeq; NP_001033646.1; NM_001038557.2.
DR   AlphaFoldDB; Q2TBK4; -.
DR   SMR; Q2TBK4; -.
DR   STRING; 9913.ENSBTAP00000003262; -.
DR   PaxDb; Q2TBK4; -.
DR   PRIDE; Q2TBK4; -.
DR   Ensembl; ENSBTAT00000003262; ENSBTAP00000003262; ENSBTAG00000002512.
DR   GeneID; 528378; -.
DR   KEGG; bta:528378; -.
DR   CTD; 115106; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002512; -.
DR   VGNC; VGNC:29757; HAUS1.
DR   eggNOG; ENOG502QSQA; Eukaryota.
DR   GeneTree; ENSGT00390000006029; -.
DR   HOGENOM; CLU_063322_0_0_1; -.
DR   InParanoid; Q2TBK4; -.
DR   OMA; YQAEGAH; -.
DR   OrthoDB; 1350537at2759; -.
DR   TreeFam; TF331717; -.
DR   Proteomes; UP000009136; Chromosome 24.
DR   Bgee; ENSBTAG00000002512; Expressed in semen and 110 other tissues.
DR   ExpressionAtlas; Q2TBK4; baseline.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0070652; C:HAUS complex; ISS:UniProtKB.
DR   GO; GO:1990498; C:mitotic spindle microtubule; ISS:UniProtKB.
DR   GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007098; P:centrosome cycle; ISS:UniProtKB.
DR   GO; GO:0051225; P:spindle assembly; ISS:UniProtKB.
DR   InterPro; IPR026243; HAUS1.
DR   PANTHER; PTHR31570; PTHR31570; 1.
DR   PRINTS; PR02087; HAUSAUGMINL1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Microtubule; Mitosis; Reference proteome.
FT   CHAIN           1..278
FT                   /note="HAUS augmin-like complex subunit 1"
FT                   /id="PRO_0000239658"
FT   COILED          53..81
FT                   /evidence="ECO:0000255"
FT   COILED          124..152
FT                   /evidence="ECO:0000255"
FT   COILED          183..277
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   278 AA;  31748 MW;  BBC02B8124FCDCBE CRC64;
     MEALEEKEAQ VAAWLKKIFG DHPIPQYEVN AWTTEILYNL SERNRIRDRD VYLVTEDLKQ
     KAKEYESEAK HLQDLLMESV NFSPASLSST GSRYLNALVD SAVVLETKDT SLASFIPAVN
     DLTSDLFRTK SKNEEIKLEL AKLEKNLTAT LVLEKCLQED LKKAELHLCT ERARVDSRLQ
     NMDFLKAKSE EFRSGIRTAE EQLSARGMDA SLSHQSLVAL SEKLAELKRQ TMPLKKKLES
     YLDLMPNPSL AQVKIEEAKR ELDTIEAELT KRVNMMEL