ID   HAUS1_RAT               Reviewed;         278 AA.
AC   Q9R0A8; A1L123;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 2.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=HAUS augmin-like complex subunit 1;
DE   AltName: Full=Coiled-coil domain-containing protein 5;
GN   Name=Haus1; Synonyms=Ccdc5;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar;
RA   Koehler D.R., Hu J., Post M.;
RT   "Novel rat gene.";
RL   Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Brown Norway/NHsdMcwi;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Contributes to mitotic spindle assembly, maintenance of
CC       centrosome integrity and completion of cytokinesis as part of the HAUS
CC       augmin-like complex. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the HAUS augmin-like complex. The complex
CC       interacts with the gamma-tubulin ring complex and this interaction is
CC       required for spindle assembly. Associates with microtubules. The
CC       interaction with microtubules is strong during mitosis, while it is
CC       weak or absent during interphase. It is unclear whether this
CC       interaction is direct or indirect (By similarity). Interacts with EML3
CC       (phosphorylated form) (By similarity). {ECO:0000250|UniProtKB:Q96CS2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96CS2}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC       {ECO:0000250|UniProtKB:Q96CS2}. Cytoplasm, cytoskeleton, spindle
CC       {ECO:0000250|UniProtKB:Q96CS2}. Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000250|UniProtKB:Q96CS2}. Note=Localizes with the spindle poles
CC       in mitotic cells. In interphase, localized at the centrosome and
CC       diffusely in the cytoplasm. Localizes to mitotic spindle microtubules
CC       (By similarity). {ECO:0000250|UniProtKB:Q96CS2}.
CC   -!- SIMILARITY: Belongs to the HAUS1 family. {ECO:0000305}.
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DR   EMBL; AF092207; AAF00052.1; -; mRNA.
DR   EMBL; CH474069; EDL84703.1; -; Genomic_DNA.
DR   EMBL; BC127484; AAI27485.1; -; mRNA.
DR   RefSeq; NP_620219.2; NM_138864.2.
DR   RefSeq; XP_017443387.1; XM_017587898.1.
DR   RefSeq; XP_017456627.1; XM_017601138.1.
DR   AlphaFoldDB; Q9R0A8; -.
DR   SMR; Q9R0A8; -.
DR   STRING; 10116.ENSRNOP00000023100; -.
DR   PhosphoSitePlus; Q9R0A8; -.
DR   jPOST; Q9R0A8; -.
DR   PaxDb; Q9R0A8; -.
DR   Ensembl; ENSRNOT00000073597; ENSRNOP00000067804; ENSRNOG00000017067.
DR   GeneID; 192228; -.
DR   KEGG; rno:192228; -.
DR   CTD; 115106; -.
DR   RGD; 619909; Haus1.
DR   eggNOG; ENOG502QSQA; Eukaryota.
DR   GeneTree; ENSGT00390000006029; -.
DR   HOGENOM; CLU_063322_0_0_1; -.
DR   InParanoid; Q9R0A8; -.
DR   OMA; YQAEGAH; -.
DR   OrthoDB; 1350537at2759; -.
DR   PhylomeDB; Q9R0A8; -.
DR   TreeFam; TF331717; -.
DR   Reactome; R-RNO-2565942; Regulation of PLK1 Activity at G2/M Transition.
DR   Reactome; R-RNO-380259; Loss of Nlp from mitotic centrosomes.
DR   Reactome; R-RNO-380270; Recruitment of mitotic centrosome proteins and complexes.
DR   Reactome; R-RNO-380284; Loss of proteins required for interphase microtubule organization from the centrosome.
DR   Reactome; R-RNO-380320; Recruitment of NuMA to mitotic centrosomes.
DR   Reactome; R-RNO-5620912; Anchoring of the basal body to the plasma membrane.
DR   Reactome; R-RNO-8854518; AURKA Activation by TPX2.
DR   PRO; PR:Q9R0A8; -.
DR   Proteomes; UP000002494; Chromosome 18.
DR   Proteomes; UP000234681; Chromosome 18.
DR   Bgee; ENSRNOG00000017067; Expressed in testis and 16 other tissues.
DR   Genevisible; Q9R0A8; RN.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0070652; C:HAUS complex; ISS:UniProtKB.
DR   GO; GO:1990498; C:mitotic spindle microtubule; ISS:UniProtKB.
DR   GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007098; P:centrosome cycle; ISS:UniProtKB.
DR   GO; GO:0051225; P:spindle assembly; ISS:UniProtKB.
DR   InterPro; IPR026243; HAUS1.
DR   PANTHER; PTHR31570; PTHR31570; 1.
DR   PRINTS; PR02087; HAUSAUGMINL1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Microtubule; Mitosis; Reference proteome.
FT   CHAIN           1..278
FT                   /note="HAUS augmin-like complex subunit 1"
FT                   /id="PRO_0000089397"
FT   COILED          128..150
FT                   /evidence="ECO:0000255"
FT   COILED          248..278
FT                   /evidence="ECO:0000255"
FT   CONFLICT        60
FT                   /note="Q -> P (in Ref. 1; AAF00052)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   278 AA;  31497 MW;  2D521AF2FD0524D7 CRC64;
     MAALEEKASQ VAEWLKKIFG DHPIPQYEMN ARTTEILYHL SERNRVRDRD VNLVIEDLRQ
     KASEYESEAK RLEDFLMESV NFSPANLSNT GSRFLNALVD SAIALEIKDT SLASFIPAVN
     DLTSDLFRTK SKSEEIKLEL GKLEKNLTAT LVLEKCLRED LKKADVHLSA ERAKAEGRLQ
     NMDFLKAKAA EFRFGIRAAE EQLSSRGMDA SLSHRSLVAL SDKLSELKQQ TIPLKKKLES
     YLDLMPNPSL AQVKIEEAKR ELDAIEAELT KKVDMMEL