HAUS2_MOUSE
ID HAUS2_MOUSE Reviewed; 234 AA.
AC Q9CQS9; A2AKH8; A2AKI1; Q3V1R1; Q9CRI2; Q9D9D0;
DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=HAUS augmin-like complex subunit 2;
DE AltName: Full=Centrosomal protein of 27 kDa;
DE Short=Cep27;
GN Name=Haus2; Synonyms=Cep27;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Contributes to mitotic spindle assembly, maintenance of
CC centrosome integrity and completion of cytokinesis as part of the HAUS
CC augmin-like complex. {ECO:0000250}.
CC -!- SUBUNIT: Component of the HAUS augmin-like complex. The complex
CC interacts with the gamma-tubulin ring complex and this interaction is
CC required for spindle assembly (By similarity). Interacts with EML3
CC (phosphorylated at 'Thr-882') (By similarity).
CC {ECO:0000250|UniProtKB:Q9NVX0}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250|UniProtKB:Q9NVX0}. Cytoplasm,
CC cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9NVX0}. Note=Localizes to
CC interphase centrosomes and to mitotic spindle microtubules.
CC {ECO:0000250|UniProtKB:Q9NVX0}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9CQS9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CQS9-2; Sequence=VSP_012224;
CC -!- SIMILARITY: Belongs to the HAUS2 family. {ECO:0000305}.
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DR EMBL; AK007106; BAB24860.1; -; mRNA.
DR EMBL; AK010445; BAB26946.1; -; mRNA.
DR EMBL; AK012086; BAB28020.1; -; mRNA.
DR EMBL; AK012960; BAB28570.1; -; mRNA.
DR EMBL; AK132300; BAE21089.1; -; mRNA.
DR EMBL; AL772299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC086677; AAH86677.1; -; mRNA.
DR CCDS; CCDS16624.1; -. [Q9CQS9-1]
DR CCDS; CCDS71120.1; -. [Q9CQS9-2]
DR RefSeq; NP_001277736.1; NM_001290807.1. [Q9CQS9-2]
DR RefSeq; NP_079751.1; NM_025475.3. [Q9CQS9-1]
DR AlphaFoldDB; Q9CQS9; -.
DR SMR; Q9CQS9; -.
DR BioGRID; 211364; 6.
DR IntAct; Q9CQS9; 7.
DR STRING; 10090.ENSMUSP00000117299; -.
DR iPTMnet; Q9CQS9; -.
DR PhosphoSitePlus; Q9CQS9; -.
DR EPD; Q9CQS9; -.
DR MaxQB; Q9CQS9; -.
DR PaxDb; Q9CQS9; -.
DR PeptideAtlas; Q9CQS9; -.
DR PRIDE; Q9CQS9; -.
DR ProteomicsDB; 270938; -. [Q9CQS9-1]
DR ProteomicsDB; 270939; -. [Q9CQS9-2]
DR Antibodypedia; 23697; 67 antibodies from 19 providers.
DR Ensembl; ENSMUST00000110706; ENSMUSP00000106334; ENSMUSG00000027285. [Q9CQS9-2]
DR Ensembl; ENSMUST00000124187; ENSMUSP00000117299; ENSMUSG00000027285. [Q9CQS9-1]
DR GeneID; 66296; -.
DR KEGG; mmu:66296; -.
DR UCSC; uc008lwo.2; mouse. [Q9CQS9-1]
DR CTD; 55142; -.
DR MGI; MGI:1913546; Haus2.
DR VEuPathDB; HostDB:ENSMUSG00000027285; -.
DR eggNOG; ENOG502RY4E; Eukaryota.
DR GeneTree; ENSGT00390000004927; -.
DR HOGENOM; CLU_096512_0_0_1; -.
DR InParanoid; Q9CQS9; -.
DR OMA; HQWDLSP; -.
DR OrthoDB; 1262354at2759; -.
DR PhylomeDB; Q9CQS9; -.
DR TreeFam; TF333194; -.
DR Reactome; R-MMU-2565942; Regulation of PLK1 Activity at G2/M Transition.
DR Reactome; R-MMU-380259; Loss of Nlp from mitotic centrosomes.
DR Reactome; R-MMU-380270; Recruitment of mitotic centrosome proteins and complexes.
DR Reactome; R-MMU-380284; Loss of proteins required for interphase microtubule organization from the centrosome.
DR Reactome; R-MMU-380320; Recruitment of NuMA to mitotic centrosomes.
DR Reactome; R-MMU-5620912; Anchoring of the basal body to the plasma membrane.
DR Reactome; R-MMU-8854518; AURKA Activation by TPX2.
DR BioGRID-ORCS; 66296; 23 hits in 72 CRISPR screens.
DR ChiTaRS; Haus2; mouse.
DR PRO; PR:Q9CQS9; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9CQS9; protein.
DR Bgee; ENSMUSG00000027285; Expressed in rostral migratory stream and 247 other tissues.
DR ExpressionAtlas; Q9CQS9; baseline and differential.
DR Genevisible; Q9CQS9; MM.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0070652; C:HAUS complex; ISS:UniProtKB.
DR GO; GO:1990498; C:mitotic spindle microtubule; ISS:UniProtKB.
DR GO; GO:0005876; C:spindle microtubule; IDA:MGI.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007098; P:centrosome cycle; ISS:UniProtKB.
DR GO; GO:0007020; P:microtubule nucleation; IBA:GO_Central.
DR GO; GO:0051225; P:spindle assembly; ISS:UniProtKB.
DR InterPro; IPR028346; HAUS2.
DR InterPro; IPR026242; HAUS2_metazoa.
DR PANTHER; PTHR16039; PTHR16039; 1.
DR Pfam; PF15003; HAUS2; 1.
DR PRINTS; PR02088; HAUSAUGMINL2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell cycle; Cell division; Coiled coil; Cytoplasm;
KW Cytoskeleton; Microtubule; Mitosis; Reference proteome.
FT CHAIN 1..234
FT /note="HAUS augmin-like complex subunit 2"
FT /id="PRO_0000089485"
FT COILED 85..105
FT /evidence="ECO:0000255"
FT COILED 162..182
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..32
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_012224"
FT CONFLICT 127
FT /note="V -> S (in Ref. 1; BAB24860)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 234 AA; 26839 MW; 5F31E0488B17F8CC CRC64;
MAAANPWDPA SSQTAAGLLL NHLVASGIVT KEMLDVSKKM APCFVNFSRL QQISDIQAEI
YQNNLELELL KLEKDTADLI HPSHLIEKCD VLQSMNNHLE AVLKEKHAIR QRLLRPMCQE
NLPLEAVYHR YVVHMLDLAV TFIEKFETHL ETVKNSPHLD ANLKQMSKAL AKMDILVNKT
EELAENILKW RELQTEISLY IPKMLTEERH LHELDIVPPL PFFPKAHTET SRAK