ID   HAUS3_XENLA             Reviewed;         597 AA.
AC   Q6DCY9;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=HAUS augmin-like complex subunit 3;
GN   Name=haus3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Contributes to mitotic spindle assembly, maintenance of
CC       centrosome integrity and completion of cytokinesis as part of the HAUS
CC       augmin-like complex. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the HAUS augmin-like complex. The complex
CC       interacts with the gamma-tubulin ring complex and this interaction is
CC       required for spindle assembly (By similarity).
CC       {ECO:0000250|UniProtKB:Q68CZ6}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250|UniProtKB:Q68CZ6}. Cytoplasm,
CC       cytoskeleton, spindle {ECO:0000250|UniProtKB:Q68CZ6}. Note=Localizes to
CC       interphase centrosomes and to mitotic spindle microtubules.
CC       {ECO:0000250|UniProtKB:Q68CZ6}.
CC   -!- SIMILARITY: Belongs to the HAUS3 family. {ECO:0000305}.
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DR   EMBL; BC077843; AAH77843.1; -; mRNA.
DR   RefSeq; NP_001086973.1; NM_001093504.1.
DR   AlphaFoldDB; Q6DCY9; -.
DR   SMR; Q6DCY9; -.
DR   DNASU; 446808; -.
DR   GeneID; 446808; -.
DR   KEGG; xla:446808; -.
DR   CTD; 446808; -.
DR   Xenbase; XB-GENE-6255109; haus3.L.
DR   OrthoDB; 380555at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 446808; Expressed in blastula and 17 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0070652; C:HAUS complex; ISS:UniProtKB.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:1990498; C:mitotic spindle microtubule; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007098; P:centrosome cycle; ISS:UniProtKB.
DR   GO; GO:0051225; P:spindle assembly; ISS:UniProtKB.
DR   InterPro; IPR026206; HAUS3.
DR   InterPro; IPR032733; HAUS3_N.
DR   PANTHER; PTHR19378; PTHR19378; 1.
DR   Pfam; PF14932; HAUS-augmin3; 1.
DR   PRINTS; PR02089; HAUSAUGMINL3.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Microtubule; Mitosis; Reference proteome.
FT   CHAIN           1..597
FT                   /note="HAUS augmin-like complex subunit 3"
FT                   /id="PRO_0000301953"
FT   COILED          91..123
FT                   /evidence="ECO:0000255"
FT   COILED          290..319
FT                   /evidence="ECO:0000255"
FT   COILED          392..428
FT                   /evidence="ECO:0000255"
FT   COILED          463..494
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   597 AA;  68024 MW;  E96D3FC40718115F CRC64;
     MSGGDRFVQT LQKLNYPKGA QLDGEDFDWL FEAVDLKPFL DWFCSAASEQ NVVPDEKLQA
     FNTLKESGKP VLDEKALDEV LKTFSISKVP AIEEVAIEKL EEEVKALQKQ KNLHIRRRNK
     LQMVESGNRQ MCLKSKDKEE ETGRAFQEVL HLLRVTNKKL NHELQSIVNG VQTLMSFFST
     PETACELSSQ PIFLSQLLLD KYLSLEEQST AALTSFTKEH FFEGMSKFVE GSDENFQLVQ
     LNVNSFGEDG TTEDKCKEMM RLQLAYICAK HKLIQMKAKS ASLKVGLQWA ENNASVVQDK
     ASQKEENLKV RITSLKNETL QIENHTNSIS NEKLPGLVRD NAQLLNMPIV KGDYDLQMAH
     QTSCSSRQDL VCDHLMKQKA SFELLQLGYE LELRKHRDVY RELGSIVQEL KESGDKLEER
     LTMLSDVNLL SASKPRSNID SKDLTSHRLY QLLDGDNTQK LFRTYDGLES VAQKLSQDIA
     SMRDQLEVSE QEHSLLLSKL DSHLKELRDF MYPEGNTLML TTPELSGEFH QLGSQLEKLN
     HITVEILGDL QLKRKMLESN KLQQIEKQLY VYFFQNEEQL KSIVGKLEAQ TGGGSSA