ID   HAUS6_DANRE             Reviewed;         794 AA.
AC   A0JMF7;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=HAUS augmin-like complex subunit 6;
GN   Name=haus6; Synonyms=fam29a; ORFNames=zgc:153242;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Contributes to mitotic spindle assembly, maintenance of
CC       centrosome integrity and completion of cytokinesis as part of the HAUS
CC       augmin-like complex. Promotes the nucleation of microtubules from the
CC       spindle through recruitment of NEDD1 and gamma-tubulin (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the HAUS augmin-like complex. The complex
CC       interacts with the gamma-tubulin ring complex and this interaction is
CC       required for spindle assembly (By similarity).
CC       {ECO:0000250|UniProtKB:Q7Z4H7}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q7Z4H7}. Cytoplasm, cytoskeleton, spindle
CC       {ECO:0000250|UniProtKB:Q7Z4H7}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome {ECO:0000250|UniProtKB:Q7Z4H7}.
CC       Note=Localizes to interphase centrosomes and to mitotic spindle
CC       microtubules. {ECO:0000250|UniProtKB:Q7Z4H7}.
CC   -!- SIMILARITY: Belongs to the HAUS6 family. {ECO:0000305}.
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DR   EMBL; BC125861; AAI25862.1; -; mRNA.
DR   RefSeq; NP_001073443.1; NM_001079974.1.
DR   AlphaFoldDB; A0JMF7; -.
DR   SMR; A0JMF7; -.
DR   STRING; 7955.ENSDARP00000089274; -.
DR   PaxDb; A0JMF7; -.
DR   PeptideAtlas; A0JMF7; -.
DR   PRIDE; A0JMF7; -.
DR   GeneID; 558814; -.
DR   KEGG; dre:558814; -.
DR   CTD; 54801; -.
DR   ZFIN; ZDB-GENE-030131-5517; haus6.
DR   eggNOG; ENOG502QV4W; Eukaryota.
DR   InParanoid; A0JMF7; -.
DR   OrthoDB; 297770at2759; -.
DR   PhylomeDB; A0JMF7; -.
DR   Reactome; R-DRE-2565942; Regulation of PLK1 Activity at G2/M Transition.
DR   Reactome; R-DRE-380259; Loss of Nlp from mitotic centrosomes.
DR   Reactome; R-DRE-380270; Recruitment of mitotic centrosome proteins and complexes.
DR   Reactome; R-DRE-380284; Loss of proteins required for interphase microtubule organization from the centrosome.
DR   Reactome; R-DRE-380320; Recruitment of NuMA to mitotic centrosomes.
DR   Reactome; R-DRE-5620912; Anchoring of the basal body to the plasma membrane.
DR   Reactome; R-DRE-8854518; AURKA Activation by TPX2.
DR   PRO; PR:A0JMF7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0070652; C:HAUS complex; ISS:UniProtKB.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:1990498; C:mitotic spindle microtubule; ISS:UniProtKB.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007098; P:centrosome cycle; ISS:UniProtKB.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0051225; P:spindle assembly; ISS:UniProtKB.
DR   InterPro; IPR026797; HAUS_6.
DR   InterPro; IPR028163; HAUS_6_N.
DR   PANTHER; PTHR16151; PTHR16151; 1.
DR   Pfam; PF14661; HAUS6_N; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Microtubule; Mitosis;
KW   Reference proteome.
FT   CHAIN           1..794
FT                   /note="HAUS augmin-like complex subunit 6"
FT                   /id="PRO_0000360990"
SQ   SEQUENCE   794 AA;  89608 MW;  3930740EE6F2CAEF CRC64;
     MSKLKKTDGK YLWWCLLCLK FKPDNVSVTK TTKHLNLGMN MFDKPNKEAF YIVIHFLFNK
     LNPTRAQDVF RNCWLVWDHK SDAEFRKVAF AWLQEIANEE GSAFPKVAAS HLLSAFGPKF
     INLMLHLAKH VMLKTMKTFN TDGMWVPEAA AVPASSEEME LKRFQLVKRQ FQRVTVEQDF
     LIQDYQKRAK VLEKSLRDLD AENAKYDSLL KEHDSITDLK EVILAKVQKL RGLWNEVDRF
     LSNHQGKRDI VASVINGQVD QYILCGQELN VKMPAALRER MERPSHQSSA VRLYEGGQPV
     LVRLLALLNE GLHVLREERE KIVGPSVQLQ NQDVQEHALL FTRSKENLNL IRWKLVKEDA
     AEIKVSIGKL EEEWECKWAN CLKNTPLTCF LEEDPVLDLV SPMVALSFEP ASEASFQASV
     ISQYPCKPHD LLEQPSKEKL DTTVAVVHLE QEVHLKPEIK ISSVATEDQD VLVPSDSCFS
     PEHVTCGTPP CETILSVIET PSPKQPCHTN LHSKPKASVL KTKAQILDLE CDNLASQFAD
     AVIMSPGNQR SDVDLGQLLN AISDPFSSRK QLCRTPESLI KDVRSSWRKA VEEGLAEKKQ
     ASWNQQDSLS WLKTPMANMN SPCKTLNLES SMSFSTNLDN CTSPPVQQGS TLHSTLSWDS
     SQMEVLTSQC SSDVIKFSIA QEEPPDLFDV SFNSDSSVEN SGEKARDEEL CLPSVGLCYL
     DETPQLTEQL CLGASSDKSV FKDSPVHLSM SKDLSHWTTD HFSLDLDRLE SLSSPPRAEN
     LTLPNLVNVN LDEY