HAUS7_MOUSE
ID HAUS7_MOUSE Reviewed; 364 AA.
AC Q8BKT8; A2AIF2; Q924Z7;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=HAUS augmin-like complex subunit 7;
DE AltName: Full=26S proteasome-associated UCH37-interacting protein 1;
DE AltName: Full=UCHL5-interacting protein;
GN Name=Haus7; Synonyms=Uchl5ip, Uip1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND INTERACTION WITH UCHL5.
RX PubMed=11163772; DOI=10.1016/s0014-5793(00)02436-4;
RA Li T., Duan W., Yang H., Lee M.K., Bte Mustafa F., Lee B.H., Teo T.S.;
RT "Identification of two proteins, S14 and UIP1, that interact with UCH37.";
RL FEBS Lett. 488:201-205(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Contributes to mitotic spindle assembly, maintenance of
CC centrosome integrity and completion of cytokinesis as part of the HAUS
CC augmin-like complex. {ECO:0000250}.
CC -!- SUBUNIT: Component of the HAUS augmin-like complex. The complex
CC interacts with the gamma-tubulin ring complex and this interaction is
CC required for spindle assembly (By similarity). Interacts with UCHL5
CC (PubMed:11163772). Interacts with EML3 (phosphorylated at 'Thr-882')
CC (By similarity). {ECO:0000250|UniProtKB:Q99871,
CC ECO:0000269|PubMed:11163772}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250|UniProtKB:Q99871}. Cytoplasm,
CC cytoskeleton, spindle {ECO:0000250|UniProtKB:Q99871}. Note=Localizes to
CC interphase centrosomes and to mitotic spindle microtubules.
CC {ECO:0000250|UniProtKB:Q99871}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BKT8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BKT8-2; Sequence=VSP_040922;
CC -!- SIMILARITY: Belongs to the HAUS7 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY029337; AAK38738.1; -; mRNA.
DR EMBL; AK050729; BAC34395.1; -; mRNA.
DR EMBL; AL732461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466650; EDL29899.1; -; Genomic_DNA.
DR EMBL; BC025464; AAH25464.1; -; mRNA.
DR CCDS; CCDS30202.1; -. [Q8BKT8-1]
DR CCDS; CCDS30203.1; -. [Q8BKT8-2]
DR RefSeq; NP_082909.1; NM_028633.3. [Q8BKT8-1]
DR RefSeq; NP_996987.1; NM_207104.1. [Q8BKT8-2]
DR AlphaFoldDB; Q8BKT8; -.
DR SMR; Q8BKT8; -.
DR BioGRID; 216223; 7.
DR IntAct; Q8BKT8; 2.
DR STRING; 10090.ENSMUSP00000033737; -.
DR iPTMnet; Q8BKT8; -.
DR PhosphoSitePlus; Q8BKT8; -.
DR EPD; Q8BKT8; -.
DR MaxQB; Q8BKT8; -.
DR PaxDb; Q8BKT8; -.
DR PeptideAtlas; Q8BKT8; -.
DR PRIDE; Q8BKT8; -.
DR ProteomicsDB; 269716; -. [Q8BKT8-1]
DR ProteomicsDB; 269717; -. [Q8BKT8-2]
DR Antibodypedia; 461; 304 antibodies from 21 providers.
DR DNASU; 73738; -.
DR Ensembl; ENSMUST00000033737; ENSMUSP00000033737; ENSMUSG00000031371. [Q8BKT8-1]
DR Ensembl; ENSMUST00000077243; ENSMUSP00000076479; ENSMUSG00000031371. [Q8BKT8-2]
DR GeneID; 73738; -.
DR KEGG; mmu:73738; -.
DR UCSC; uc009tlu.1; mouse. [Q8BKT8-1]
DR UCSC; uc009tlv.1; mouse. [Q8BKT8-2]
DR CTD; 55559; -.
DR MGI; MGI:1920988; Haus7.
DR VEuPathDB; HostDB:ENSMUSG00000031371; -.
DR eggNOG; ENOG502RYVK; Eukaryota.
DR GeneTree; ENSGT00390000003937; -.
DR HOGENOM; CLU_065168_0_0_1; -.
DR InParanoid; Q8BKT8; -.
DR OMA; PESDPWP; -.
DR OrthoDB; 1184888at2759; -.
DR PhylomeDB; Q8BKT8; -.
DR TreeFam; TF333445; -.
DR Reactome; R-MMU-2565942; Regulation of PLK1 Activity at G2/M Transition.
DR Reactome; R-MMU-380259; Loss of Nlp from mitotic centrosomes.
DR Reactome; R-MMU-380270; Recruitment of mitotic centrosome proteins and complexes.
DR Reactome; R-MMU-380284; Loss of proteins required for interphase microtubule organization from the centrosome.
DR Reactome; R-MMU-380320; Recruitment of NuMA to mitotic centrosomes.
DR Reactome; R-MMU-5620912; Anchoring of the basal body to the plasma membrane.
DR Reactome; R-MMU-8854518; AURKA Activation by TPX2.
DR BioGRID-ORCS; 73738; 28 hits in 76 CRISPR screens.
DR PRO; PR:Q8BKT8; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q8BKT8; protein.
DR Bgee; ENSMUSG00000031371; Expressed in yolk sac and 234 other tissues.
DR Genevisible; Q8BKT8; MM.
DR GO; GO:0005813; C:centrosome; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0070652; C:HAUS complex; ISS:UniProtKB.
DR GO; GO:1990498; C:mitotic spindle microtubule; ISS:UniProtKB.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0051011; F:microtubule minus-end binding; IBA:GO_Central.
DR GO; GO:0031996; F:thioesterase binding; ISS:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007098; P:centrosome cycle; ISS:UniProtKB.
DR GO; GO:0051225; P:spindle assembly; ISS:UniProtKB.
DR InterPro; IPR029711; Haus7-like.
DR PANTHER; PTHR14352; PTHR14352; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell cycle; Cell division; Cytoplasm; Cytoskeleton;
KW Microtubule; Mitosis; Reference proteome.
FT CHAIN 1..364
FT /note="HAUS augmin-like complex subunit 7"
FT /id="PRO_0000097553"
FT REGION 179..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 118..233
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_040922"
FT CONFLICT 62
FT /note="K -> R (in Ref. 2; BAC34395)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 364 AA; 40656 MW; 53B9AE710D7C058F CRC64;
MAEEGAGAGS DDSYYKDVGD DCVVKAAVEV FEKLKGVNCP FLDGLYITEP KTIMELLCRP
SKYRLDILEW MCIRVCPSLQ DKFISLKGNA LDLKIQEMLK LGHELMFCAP DDQDLLMGRE
CPQKQLQFMD KILDMMQSLA TGCSSSSSLK EHLEDTTEKN EALLGELFSS PNLRAILKPE
SDPWPLDMQS SLNKQSDDLP KADPSAQSEG EKVADLARQL QESATKLQTL RDQCFAQHKA
GTDTSTIDQK LRLVISDFYQ LILAFLQVYD DELRECCQRP VPSLHPSGPI IQAVYQTLAS
CGQLLRAVME IADTSAEAMK AARKQEGEPN CWSSNNSGIS LAARIDEVTQ KYKILTDRFH
RGTR
