HAVR1_RAT
ID HAVR1_RAT Reviewed; 307 AA.
AC O54947;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Hepatitis A virus cellular receptor 1 homolog;
DE Short=HAVcr-1;
DE AltName: Full=Kidney injury molecule 1;
DE Short=KIM-1;
DE AltName: Full=T cell immunoglobulin and mucin domain-containing protein 1;
DE Short=TIMD-1;
DE AltName: CD_antigen=CD365;
DE Flags: Precursor;
GN Name=Havcr1; Synonyms=Kim1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley; TISSUE=Kidney;
RX PubMed=9461608; DOI=10.1074/jbc.273.7.4135;
RA Ichimura T., Bonventre J.V., Bailly V., Wei H., Hession C.A., Cate R.L.,
RA Sanicola M.;
RT "Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion
RT molecule containing a novel immunoglobulin domain, is up-regulated in renal
RT cells after injury.";
RL J. Biol. Chem. 273:4135-4142(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Phosphatidylserine receptor that plays an important
CC functional role in regulatory B-cells homeostasis including generation,
CC expansion and suppressor functions (By similarity). As P-
CC selectin/SELPLG ligand, plays a specialized role in activated but not
CC naive T-cell trafficking during inflammatory responses. Controls
CC thereby T-cell accumulation in the inflamed central nervous system
CC (CNS) and the induction of autoimmune disease (By similarity).
CC Regulates also expression of various anti-inflammatory cytokines and
CC co-inhibitory ligands including IL10. Acts as regulator of T-cell
CC proliferation (By similarity). May play a role in kidney injury and
CC repair (By similarity). {ECO:0000250|UniProtKB:Q5QNS5,
CC ECO:0000250|UniProtKB:Q96D42}.
CC -!- SUBUNIT: Interacts with STAM. Interacts with SELPLG.
CC {ECO:0000250|UniProtKB:Q96D42}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96D42};
CC Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q96D42}.
CC -!- TISSUE SPECIFICITY: Expressed at a low level in normal kidney but are
CC increased dramatically in postischemic kidney. Expressed in
CC proliferating bromodeoxyuridine-positive and dedifferentiated vimentin-
CC positive epithelial cells in regenerating proximal tubules.
CC {ECO:0000269|PubMed:9461608}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. TIM family.
CC {ECO:0000305}.
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DR EMBL; AF035963; AAC53546.1; -; mRNA.
DR EMBL; BC061820; AAH61820.1; -; mRNA.
DR RefSeq; NP_775172.1; NM_173149.2.
DR AlphaFoldDB; O54947; -.
DR SMR; O54947; -.
DR STRING; 10116.ENSRNOP00000009573; -.
DR GlyGen; O54947; 1 site.
DR PaxDb; O54947; -.
DR GeneID; 286934; -.
DR KEGG; rno:286934; -.
DR UCSC; RGD:708425; rat.
DR CTD; 26762; -.
DR RGD; 708425; Havcr1.
DR eggNOG; ENOG502S454; Eukaryota.
DR InParanoid; O54947; -.
DR OrthoDB; 1147868at2759; -.
DR PhylomeDB; O54947; -.
DR PRO; PR:O54947; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; IDA:RGD.
DR GO; GO:0005903; C:brush border; ISO:RGD.
DR GO; GO:0009986; C:cell surface; IDA:RGD.
DR GO; GO:0005737; C:cytoplasm; IDA:RGD.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; ISO:RGD.
DR GO; GO:0045335; C:phagocytic vesicle; IDA:RGD.
DR GO; GO:0001786; F:phosphatidylserine binding; ISO:RGD.
DR GO; GO:0001618; F:virus receptor activity; ISO:RGD.
DR GO; GO:0006911; P:phagocytosis, engulfment; IMP:RGD.
DR GO; GO:0033005; P:positive regulation of mast cell activation; ISO:RGD.
DR GO; GO:0046677; P:response to antibiotic; IEP:RGD.
DR GO; GO:0032496; P:response to lipopolysaccharide; ISO:RGD.
DR GO; GO:0010046; P:response to mycotoxin; IEP:RGD.
DR GO; GO:0007584; P:response to nutrient; IEP:RGD.
DR GO; GO:0033574; P:response to testosterone; IEP:RGD.
DR GO; GO:0009611; P:response to wounding; ISO:RGD.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEP:RGD.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..307
FT /note="Hepatitis A virus cellular receptor 1 homolog"
FT /id="PRO_0000014983"
FT TOPO_DOM 22..235
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..307
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 22..124
FT /note="Ig-like V-type"
FT REGION 129..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 206
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 37..108
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 49..60
FT /evidence="ECO:0000250|UniProtKB:Q5QNS5"
FT DISULFID 55..107
FT /evidence="ECO:0000250|UniProtKB:Q5QNS5"
SQ SEQUENCE 307 AA; 33964 MW; 736D1DD1F1549760 CRC64;
MVQLQVFISG LLLLLPGSVD SYEVVKGVVG HPVTIPCTYS TRGGITTTCW GRGQCPYSSC
QNILIWTNGY QVTYRSSGRY NIKGRISEGD VSLTIENSVD SDSGLYCCRV EIPGWFNDQK
MTFSLEVKPE IPTSPPTRPT TTRPTTTRPT TISTRSTHVP TSTRVSTSTP TPEQTQTHKP
EITTFYAHET TAEVTETPSY TPADWNGTVT SSEEAWNNHT VRIPLRKPQR NPTKGFYVGM
SVAALLLLLL ASTVVVTRYI IIRKKMGSLS FVAFHVSKSR ALQNAAIVHP RAEDNIYIIE
DRSRGAE
