HB21_BOVIN
ID HB21_BOVIN Reviewed; 261 AA.
AC Q9TVC8; O77825; Q95541;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=BoLa class II histocompatibility antigen, DQB*0101 beta chain;
DE Short=DQB1*1A;
DE Flags: Precursor;
GN Name=BoLA-DQB {ECO:0000312|EMBL:CAA77078.1};
GN Synonyms=DQB1 {ECO:0000312|EMBL:AAB21511.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1] {ECO:0000312|EMBL:CAA77078.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Blood {ECO:0000312|EMBL:CAA77078.1};
RX PubMed=11132144; DOI=10.1007/s002510000257;
RA Russell G.C.;
RT "Sequence duplication at the 3' end of BoLA-DQB genes suggests multiple
RT allelic lineages.";
RL Immunogenetics 52:101-106(2000).
RN [2] {ECO:0000312|EMBL:AAB21511.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-121.
RX PubMed=1537611; DOI=10.1007/bf00185115;
RA Sigurdardottir S., Borsch C., Gustafsson K., Andersson L.;
RT "Gene duplications and sequence polymorphism of bovine class II DQB
RT genes.";
RL Immunogenetics 35:205-213(1992).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MHC class II family. {ECO:0000255}.
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DR EMBL; Y18201; CAA77078.1; -; mRNA.
DR EMBL; S83910; AAB21511.1; -; Genomic_DNA.
DR PIR; I47060; I47060.
DR AlphaFoldDB; Q9TVC8; -.
DR SMR; Q9TVC8; -.
DR STRING; 9913.ENSBTAP00000026100; -.
DR PRIDE; Q9TVC8; -.
DR eggNOG; ENOG502RYBQ; Eukaryota.
DR InParanoid; Q9TVC8; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0042613; C:MHC class II protein complex; IBA:GO_Central.
DR GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IBA:GO_Central.
DR GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.10.320.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR000353; MHC_II_b_N.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00969; MHC_II_beta; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00921; MHC_II_beta; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF54452; SSF54452; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 2: Evidence at transcript level;
KW Adaptive immunity; Disulfide bond; Glycoprotein; Immunity; Membrane;
KW MHC II; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..261
FT /note="BoLa class II histocompatibility antigen, DQB*0101
FT beta chain"
FT /id="PRO_5000147334"
FT TOPO_DOM 33..230
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 252..261
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 129..233
FT /note="Ig-like C1-type"
FT /evidence="ECO:0000255"
FT REGION 33..126
FT /note="Beta-1"
FT /evidence="ECO:0000255"
FT REGION 127..220
FT /note="Beta-2"
FT /evidence="ECO:0000255"
FT REGION 221..230
FT /note="Connecting peptide"
FT /evidence="ECO:0000255"
FT CARBOHYD 51
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 47..111
FT /evidence="ECO:0000250|UniProtKB:P06343,
FT ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 149..205
FT /evidence="ECO:0000250|UniProtKB:P06343,
FT ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 261 AA; 30122 MW; 9BB83ABA7CCC49F8 CRC64;
MSGMVALWIP RGLWTAVVMV TLVMLSTPGA EGRDSPKDFV YQFKGLCYFT NGTERVRYVT
RYIYNQEENV RFDSDWDEYR AVTPLGRPDA EYFNSQKDFL EQTRAEADTV CRHNYQVEAP
FTWQRQVEPT VTIFLSRTEA LNHHNLLVCS VTDFYPGQIK VRWFRNDQEE TAGVVATPLI
RNGDWTFQLF MMLEMTPQRG DVYTCRVEHP SLQSPIMVEW RAQSESAQSK MLSGIGGFVL
GLIFLGLGLI VHHRSQKGLM R
