HB2B_RAT
ID HB2B_RAT Reviewed; 263 AA.
AC P29826;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=Rano class II histocompatibility antigen, B-1 beta chain;
DE AltName: Full=RT1 class II histocompatibility antigen, B-1 beta chain;
DE AltName: Full=RT1.B-beta(1);
DE Flags: Precursor;
GN Name=RT1-Bb;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Lewis; TISSUE=Bone marrow;
RX PubMed=1859846; DOI=10.1016/0167-4781(91)90189-s;
RA Syha-Jedelhauser J., Wendling U., Reske K.;
RT "Complete coding nucleotide sequence of cDNA for the class II RT1.B beta I
RT chain of the Lewis rat.";
RL Biochim. Biophys. Acta 1089:414-416(1991).
CC -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC immune system.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MHC class II family. {ECO:0000305}.
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DR EMBL; X56596; CAA39934.1; -; mRNA.
DR PIR; S16999; HLRTBB.
DR PDB; 6NF7; X-ray; 2.90 A; C/F/I/L/O=64-75.
DR PDBsum; 6NF7; -.
DR AlphaFoldDB; P29826; -.
DR SMR; P29826; -.
DR STRING; 10116.ENSRNOP00000000525; -.
DR GlyGen; P29826; 1 site.
DR PaxDb; P29826; -.
DR UCSC; RGD:3469; rat.
DR RGD; 3469; RT1-Bb.
DR eggNOG; ENOG502RYBQ; Eukaryota.
DR InParanoid; P29826; -.
DR PhylomeDB; P29826; -.
DR Reactome; R-RNO-202424; Downstream TCR signaling.
DR Reactome; R-RNO-202427; Phosphorylation of CD3 and TCR zeta chains.
DR Reactome; R-RNO-202430; Translocation of ZAP-70 to Immunological synapse.
DR Reactome; R-RNO-202433; Generation of second messenger molecules.
DR Reactome; R-RNO-2132295; MHC class II antigen presentation.
DR Reactome; R-RNO-389948; PD-1 signaling.
DR PRO; PR:P29826; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0009986; C:cell surface; IDA:RGD.
DR GO; GO:0005769; C:early endosome; ISO:RGD.
DR GO; GO:0009897; C:external side of plasma membrane; ISO:RGD.
DR GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; ISO:RGD.
DR GO; GO:0042613; C:MHC class II protein complex; ISO:RGD.
DR GO; GO:0005771; C:multivesicular body; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR GO; GO:0042605; F:peptide antigen binding; ISO:RGD.
DR GO; GO:1990405; F:protein antigen binding; ISO:RGD.
DR GO; GO:0044877; F:protein-containing complex binding; IDA:RGD.
DR GO; GO:0015643; F:toxic substance binding; ISO:RGD.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:RGD.
DR GO; GO:0019882; P:antigen processing and presentation; ISO:RGD.
DR GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; ISO:RGD.
DR GO; GO:0048002; P:antigen processing and presentation of peptide antigen; ISO:RGD.
DR GO; GO:0002344; P:B cell affinity maturation; ISO:RGD.
DR GO; GO:0071549; P:cellular response to dexamethasone stimulus; IEP:RGD.
DR GO; GO:0071385; P:cellular response to glucocorticoid stimulus; IEP:RGD.
DR GO; GO:0071346; P:cellular response to interferon-gamma; ISO:RGD.
DR GO; GO:0071315; P:cellular response to morphine; IEP:RGD.
DR GO; GO:0050832; P:defense response to fungus; IEP:RGD.
DR GO; GO:0006959; P:humoral immune response; ISO:RGD.
DR GO; GO:0006955; P:immune response; ISO:RGD.
DR GO; GO:0042130; P:negative regulation of T cell proliferation; IDA:RGD.
DR GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR GO; GO:0046635; P:positive regulation of alpha-beta T cell activation; ISO:RGD.
DR GO; GO:0002579; P:positive regulation of antigen processing and presentation; ISO:RGD.
DR GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR GO; GO:0002827; P:positive regulation of T-helper 1 type immune response; ISO:RGD.
DR GO; GO:0050852; P:T cell receptor signaling pathway; ISO:RGD.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.10.320.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR000353; MHC_II_b_N.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00969; MHC_II_beta; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00921; MHC_II_beta; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF54452; SSF54452; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Adaptive immunity; Disulfide bond; Glycoprotein; Immunity;
KW Isopeptide bond; Membrane; MHC II; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix; Ubl conjugation.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..263
FT /note="Rano class II histocompatibility antigen, B-1 beta
FT chain"
FT /id="PRO_0000019005"
FT TOPO_DOM 28..224
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 246..263
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 123..211
FT /note="Ig-like C1-type"
FT REGION 28..120
FT /note="Beta-1"
FT REGION 121..214
FT /note="Beta-2"
FT REGION 215..224
FT /note="Connecting peptide"
FT CARBOHYD 46
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 42..104
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 143..199
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CROSSLNK 251
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250|UniProtKB:P13762"
SQ SEQUENCE 263 AA; 29935 MW; 11127ABBE6139204 CRC64;
MALQTPSFLL PAAVVVLMVL SSPGTEGRDS PRDFVYQFKG LCYYTNGTQR IRDVIRYIYN
QEEYLRYDSD VGEYRALTEL GRPSAEYFNK QYLEQTRAEL DTVCRHNYEG SEVRTSLRRL
EQPNVAISLS RTEALNHHNL LVCSVTDFYP AQIKVRWFRN GQEETAGVVS TQLIRNGDWT
FQILVMLEMT PQRGEVYICH VDHPSLESPV TVEWRAQSES AQSKMLSGIG GFVLGVIFLG
LGLFIRHKRQ KGPRGPPPAG LLQ
