ID   HB2C_PIG                Reviewed;         261 AA.
AC   P15982;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=SLA class II histocompatibility antigen, DQ haplotype C beta chain;
DE   Flags: Precursor;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2391424;
RA   Gustafsson K., Leguern C., Hirsch F., Germana S., Pratt K., Sachs D.H.;
RT   "Class II genes of miniature swine. IV. Characterization and expression of
RT   two allelic class II DQB cDNA clones.";
RL   J. Immunol. 145:1946-1951(1990).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MHC class II family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M31497; AAA31084.1; -; mRNA.
DR   EMBL; M32117; AAA53110.1; -; mRNA.
DR   PIR; A60404; A60404.
DR   RefSeq; NP_001107166.1; NM_001113694.1.
DR   AlphaFoldDB; P15982; -.
DR   SMR; P15982; -.
DR   STRING; 9823.ENSSSCP00000001575; -.
DR   PaxDb; P15982; -.
DR   PeptideAtlas; P15982; -.
DR   PRIDE; P15982; -.
DR   GeneID; 100037921; -.
DR   KEGG; ssc:100037921; -.
DR   CTD; 100037921; -.
DR   eggNOG; ENOG502RYBQ; Eukaryota.
DR   OrthoDB; 1186163at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042613; C:MHC class II protein complex; IBA:GO_Central.
DR   GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IBA:GO_Central.
DR   GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR   GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.10.320.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR000353; MHC_II_b_N.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00969; MHC_II_beta; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00921; MHC_II_beta; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF54452; SSF54452; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   2: Evidence at transcript level;
KW   Adaptive immunity; Disulfide bond; Glycoprotein; Immunity; Membrane;
KW   MHC II; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..31
FT   CHAIN           32..261
FT                   /note="SLA class II histocompatibility antigen, DQ
FT                   haplotype C beta chain"
FT                   /id="PRO_0000019008"
FT   TOPO_DOM        32..230
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        252..261
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          129..233
FT                   /note="Ig-like C1-type"
FT   REGION          32..126
FT                   /note="Beta-1"
FT   REGION          127..220
FT                   /note="Beta-2"
FT   REGION          221..230
FT                   /note="Connecting peptide"
FT   CARBOHYD        51
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        47..111
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        149..205
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   261 AA;  29550 MW;  AA9581F2A3B1969D CRC64;
     MSGMVALRLP RGLWTAALTV MLVVLGAPVA EGRDSPQDFV FQFKGECYFY NGTQRVRGVA
     RYIYNQEEHL RFDSDVGEFR AVTPLGRPEA DSWNSQKDVL EQMRAEVDRV CKHNYQIEEG
     TTLQRRVQPT VTISPSKAEA LNHHNLLVCA VTDFYPSQVK VQWFRNGQEE TAGVVSTPLI
     RNGDWTYQVL VMLEMNLQRG DVYTCRVEHS SLQNPILVEW RAQSESAQSK MLSGVGGFVL
     GLIFLGLGLF IRHRSQKGLV R