ID   HB2D_CANLF              Reviewed;         266 AA.
AC   P18470;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=DLA class II histocompatibility antigen, DR-1 beta chain;
DE   Flags: Precursor;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2370085; DOI=10.1007/bf02115018;
RA   Sarmiento U.M., Storb R.;
RT   "Nucleotide sequence of a dog DRB cDNA clone.";
RL   Immunogenetics 31:396-399(1990).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MHC class II family. {ECO:0000305}.
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DR   EMBL; M29611; AAA30874.1; -; mRNA.
DR   PIR; A45844; A45844.
DR   RefSeq; NP_001014768.1; NM_001014768.1.
DR   AlphaFoldDB; P18470; -.
DR   SMR; P18470; -.
DR   STRING; 9612.ENSCAFP00000001156; -.
DR   PaxDb; P18470; -.
DR   GeneID; 474860; -.
DR   KEGG; cfa:474860; -.
DR   CTD; 3123; -.
DR   eggNOG; ENOG502RYBQ; Eukaryota.
DR   OrthoDB; 1249505at2759; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR   GO; GO:0042613; C:MHC class II protein complex; IBA:GO_Central.
DR   GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IBA:GO_Central.
DR   GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR   GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.10.320.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR000353; MHC_II_b_N.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00969; MHC_II_beta; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00921; MHC_II_beta; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF54452; SSF54452; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   2: Evidence at transcript level;
KW   Adaptive immunity; Disulfide bond; Glycoprotein; Immunity; Membrane;
KW   MHC II; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..29
FT   CHAIN           30..266
FT                   /note="DLA class II histocompatibility antigen, DR-1 beta
FT                   chain"
FT                   /id="PRO_0000019010"
FT   TOPO_DOM        30..227
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        251..266
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          126..214
FT                   /note="Ig-like C1-type"
FT   REGION          30..124
FT                   /note="Beta-1"
FT   REGION          125..227
FT                   /note="Beta-2"
FT   CARBOHYD        48
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        44..108
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        146..202
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   266 AA;  30151 MW;  4E8297BBF1ACDD67 CRC64;
     MVCLCFLGGS WMTALMLILM VLNPPFAWAR DTPPHFLEVA KSECYFTNGT ERVRFVERYI
     HNREEFVRFD SDVGEFRAVT ELGRPVAESW NGQKEILEQE RATVDTYCRH NYGVIESFTV
     QRRVEPTVTV YPTKTQTLQH HNLLVCSVNG FYPGHIEVRW LRNGQEEEAG VVSTGLIRNG
     DWTFQILVML EIVPQSGEVY TCQVEHPSLT SPVTVEWRAQ SDSAQSKMLS GIGGFVLGLL
     FLAVGLFIYF RNQKGHSGLQ PTGLLS