HB2D_PIG
ID HB2D_PIG Reviewed; 258 AA.
AC P15983;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=SLA class II histocompatibility antigen, DQ haplotype D beta chain;
DE Flags: Precursor;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2391424;
RA Gustafsson K., Leguern C., Hirsch F., Germana S., Pratt K., Sachs D.H.;
RT "Class II genes of miniature swine. IV. Characterization and expression of
RT two allelic class II DQB cDNA clones.";
RL J. Immunol. 145:1946-1951(1990).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MHC class II family. {ECO:0000305}.
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DR EMBL; M31498; AAA31085.1; -; mRNA.
DR AlphaFoldDB; P15983; -.
DR SMR; P15983; -.
DR PeptideAtlas; P15983; -.
DR PRIDE; P15983; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0042613; C:MHC class II protein complex; IBA:GO_Central.
DR GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IBA:GO_Central.
DR GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.10.320.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR000353; MHC_II_b_N.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00969; MHC_II_beta; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00921; MHC_II_beta; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF54452; SSF54452; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 2: Evidence at transcript level;
KW Adaptive immunity; Disulfide bond; Glycoprotein; Immunity; Membrane;
KW MHC II; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..31
FT CHAIN 32..258
FT /note="SLA class II histocompatibility antigen, DQ
FT haplotype D beta chain"
FT /id="PRO_0000019009"
FT TOPO_DOM 32..227
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..258
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 126..230
FT /note="Ig-like C1-type"
FT REGION 32..123
FT /note="Beta-1"
FT REGION 124..217
FT /note="Beta-2"
FT REGION 218..227
FT /note="Connecting peptide"
FT CARBOHYD 48
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 44..108
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 146..202
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 258 AA; 29262 MW; E3AC75110AED47C3 CRC64;
MVALRLPRGL WTAALTVMLV VLGAPVAEGR DSPQDFVVQF KGECYFYNGT QRVWSVDRYI
YNQEEFLRFD SDMGEYRAVT PLGRPDADYL NGQKEALEQK RAELDTVCKH NYQIEEGTTL
QRRVQPTVTI SPSKAEALNH HNLLVCAVTD FYPSQVKVQW FRNGQEETAG VVSTPLIRNG
DWTYQVLVML EMNLQRGDVY TCRVEHSSLQ SPILVEWRAQ SESAQSKMLS GVGGFVLGLI
FLGLGLFIRH RSQKGLVR
