HB2D_RAT
ID HB2D_RAT Reviewed; 264 AA.
AC P18211;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 25-MAY-2022, entry version 127.
DE RecName: Full=Rano class II histocompatibility antigen, D-1 beta chain;
DE AltName: Full=RT1 class II histocompatibility antigen, D-1 beta chain;
DE Flags: Precursor;
GN Name=RT1-Db1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Lewis familiaris; TISSUE=Bone marrow;
RX PubMed=2388838; DOI=10.1093/nar/18.15.4598;
RA Syha-Jedelhauser J., Reske K.;
RT "Sequence of rat cDNA clone pLR beta 112 coding for the RT1.D beta I
RT chain.";
RL Nucleic Acids Res. 18:4598-4598(1990).
CC -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC immune system.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MHC class II family. {ECO:0000305}.
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DR EMBL; X53054; CAA37221.1; -; mRNA.
DR PIR; B60497; B60497.
DR PIR; S10989; S10989.
DR AlphaFoldDB; P18211; -.
DR SMR; P18211; -.
DR STRING; 10116.ENSRNOP00000000522; -.
DR GlyGen; P18211; 1 site.
DR iPTMnet; P18211; -.
DR PhosphoSitePlus; P18211; -.
DR PRIDE; P18211; -.
DR UCSC; RGD:1593282; rat.
DR RGD; 1593282; RT1-Db1.
DR eggNOG; ENOG502RYBQ; Eukaryota.
DR InParanoid; P18211; -.
DR PhylomeDB; P18211; -.
DR Reactome; R-RNO-202424; Downstream TCR signaling.
DR Reactome; R-RNO-202427; Phosphorylation of CD3 and TCR zeta chains.
DR Reactome; R-RNO-202430; Translocation of ZAP-70 to Immunological synapse.
DR Reactome; R-RNO-202433; Generation of second messenger molecules.
DR Reactome; R-RNO-2132295; MHC class II antigen presentation.
DR Reactome; R-RNO-389948; PD-1 signaling.
DR PRO; PR:P18211; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0009986; C:cell surface; ISO:RGD.
DR GO; GO:0009897; C:external side of plasma membrane; ISO:RGD.
DR GO; GO:0001772; C:immunological synapse; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031902; C:late endosome membrane; ISO:RGD.
DR GO; GO:0005765; C:lysosomal membrane; ISO:RGD.
DR GO; GO:0042613; C:MHC class II protein complex; ISO:RGD.
DR GO; GO:0042609; F:CD4 receptor binding; ISO:RGD.
DR GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR GO; GO:0032395; F:MHC class II receptor activity; ISO:RGD.
DR GO; GO:0042605; F:peptide antigen binding; ISO:RGD.
DR GO; GO:0030247; F:polysaccharide binding; ISO:RGD.
DR GO; GO:0042608; F:T cell receptor binding; ISO:RGD.
DR GO; GO:0002491; P:antigen processing and presentation of endogenous peptide antigen via MHC class II; ISO:RGD.
DR GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; ISO:RGD.
DR GO; GO:0016045; P:detection of bacterium; ISO:RGD.
DR GO; GO:0006959; P:humoral immune response; ISO:RGD.
DR GO; GO:0006955; P:immune response; ISO:RGD.
DR GO; GO:0002437; P:inflammatory response to antigenic stimulus; ISO:RGD.
DR GO; GO:0030225; P:macrophage differentiation; ISO:RGD.
DR GO; GO:0002469; P:myeloid dendritic cell antigen processing and presentation; ISO:RGD.
DR GO; GO:0002862; P:negative regulation of inflammatory response to antigenic stimulus; ISO:RGD.
DR GO; GO:0032689; P:negative regulation of interferon-gamma production; ISO:RGD.
DR GO; GO:0042130; P:negative regulation of T cell proliferation; ISO:RGD.
DR GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; ISO:RGD.
DR GO; GO:2000516; P:positive regulation of CD4-positive, alpha-beta T cell activation; ISO:RGD.
DR GO; GO:0032831; P:positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; ISO:RGD.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:RGD.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; ISO:RGD.
DR GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; ISO:RGD.
DR GO; GO:0033674; P:positive regulation of kinase activity; ISO:RGD.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:RGD.
DR GO; GO:0043382; P:positive regulation of memory T cell differentiation; ISO:RGD.
DR GO; GO:0045657; P:positive regulation of monocyte differentiation; ISO:RGD.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; ISO:RGD.
DR GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; ISO:RGD.
DR GO; GO:0002842; P:positive regulation of T cell mediated immune response to tumor cell; ISO:RGD.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0046598; P:positive regulation of viral entry into host cell; ISO:RGD.
DR GO; GO:0051262; P:protein tetramerization; ISO:RGD.
DR GO; GO:0032653; P:regulation of interleukin-10 production; ISO:RGD.
DR GO; GO:0032673; P:regulation of interleukin-4 production; ISO:RGD.
DR GO; GO:0045622; P:regulation of T-helper cell differentiation; ISO:RGD.
DR GO; GO:0071548; P:response to dexamethasone; IEP:RGD.
DR GO; GO:0034341; P:response to interferon-gamma; ISO:RGD.
DR GO; GO:0010033; P:response to organic substance; IEP:RGD.
DR GO; GO:0007165; P:signal transduction; ISO:RGD.
DR GO; GO:0050852; P:T cell receptor signaling pathway; ISO:RGD.
DR GO; GO:0042088; P:T-helper 1 type immune response; ISO:RGD.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.10.320.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR000353; MHC_II_b_N.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00969; MHC_II_beta; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00921; MHC_II_beta; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF54452; SSF54452; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 2: Evidence at transcript level;
KW Adaptive immunity; Disulfide bond; Glycoprotein; Immunity; Membrane;
KW MHC II; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..26
FT CHAIN 27..264
FT /note="Rano class II histocompatibility antigen, D-1 beta
FT chain"
FT /id="PRO_0000019006"
FT TOPO_DOM 27..226
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..264
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 124..228
FT /note="Ig-like C1-type"
FT REGION 27..120
FT /note="Beta-1"
FT REGION 121..215
FT /note="Beta-2"
FT REGION 216..226
FT /note="Connecting peptide"
FT CARBOHYD 46
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 42..106
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 144..200
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 264 AA; 29876 MW; 158F357355177DA1 CRC64;
MVWLARDSCV AAVILLLTVL SPPVALVRDP TPRFLEQVKG ECHFYNGTQR VRFLARYIYN
REEYTRFDSD VGEFRAVTEL GRPSAEYYNK QKEYMEQLRA TVDTACKHDY EISESFLVPR
TVEPKVTVYP SKTQPLEHHN LLVCSVSDFY PGSVEVRWFR NGEEEKDGLV STGLIRNGDW
TFQLLVMLET VPQGGEVYTC QVEHPSLPSP VRVEWKAQST SAQNKKMSGV GGIVLGLLFL
GAGLFVYFRN QKGQSGLQPT GLLN
