ID   HB2L_CHICK              Reviewed;         231 AA.
AC   P23068;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Class II histocompatibility antigen, B-L beta chain;
DE   Flags: Fragment;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CLONE P14).
RX   PubMed=2841107; DOI=10.1002/j.1460-2075.1988.tb02910.x;
RA   Bourlet Y., Behar G., Guillemot F., Frechin N., Billault A., Chausse A.M.,
RA   Zoorob R., Auffray C.;
RT   "Isolation of chicken major histocompatibility complex class II (B-L) beta
RT   chain sequences: comparison with mammalian beta chains and expression in
RT   lymphoid organs.";
RL   EMBO J. 7:1031-1039(1988).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MHC class II family. {ECO:0000305}.
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DR   EMBL; X07447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; B49055; B49055.
DR   PIR; S00475; HLCHBL.
DR   AlphaFoldDB; P23068; -.
DR   SMR; P23068; -.
DR   STRING; 9031.ENSGALP00000000193; -.
DR   PaxDb; P23068; -.
DR   VEuPathDB; HostDB:geneid_101748499; -.
DR   eggNOG; ENOG502RYBQ; Eukaryota.
DR   PhylomeDB; P23068; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042613; C:MHC class II protein complex; IBA:GO_Central.
DR   GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IBA:GO_Central.
DR   GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR   GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.10.320.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR000353; MHC_II_b_N.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00969; MHC_II_beta; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00921; MHC_II_beta; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF54452; SSF54452; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   3: Inferred from homology;
KW   Adaptive immunity; Disulfide bond; Glycoprotein; Immunity; Membrane;
KW   MHC II; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           <1..231
FT                   /note="Class II histocompatibility antigen, B-L beta chain"
FT                   /id="PRO_0000080756"
FT   TOPO_DOM        <1..194
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..231
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          91..179
FT                   /note="Ig-like C1-type"
FT   REGION          <1..89
FT                   /note="Beta-1"
FT   REGION          90..182
FT                   /note="Beta-2"
FT   REGION          183..194
FT                   /note="Connecting peptide"
FT   CARBOHYD        14
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        10..74
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        111..167
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         1
SQ   SEQUENCE   231 AA;  26278 MW;  06ADED95FAF8B22A CRC64;
     FFQWSATVEC HFLNGTERVR FLVRHVYNRQ QYVHFDSDVG LFVADTVLGE PSAKLFNSQP
     DVLEKNRAAV EMLCNYNYEI VAPLTLQRRE PKVRIFALQS GSLPQTDRLA CYVTGFYPPE
     IEVKWFQNGQ EETERVVSTD VIQNGDWTYQ VLVVLEISPR HGDSYVCQVE HTSLQQPITQ
     RWEPPGDVSR SKLLMGVGGF VLGLVYLALG IFFFLCSKKG QPDPTSPGIL N