HB2P_RABIT
ID HB2P_RABIT Reviewed; 257 AA.
AC P20756;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=RLA class II histocompatibility antigen, DP beta chain;
DE AltName: Full=D10 haplotype;
DE Flags: Precursor;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2834455;
RA Sittisombut N., Mordacq J., Knight K.L.;
RT "Rabbit MHC. II. Sequence analysis of the R-DP alpha- and beta-genes.";
RL J. Immunol. 140:3237-3243(1988).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MHC class II family. {ECO:0000305}.
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DR EMBL; M21468; AAA31393.1; -; Genomic_DNA.
DR EMBL; M21465; AAA31393.1; JOINED; Genomic_DNA.
DR EMBL; M21466; AAA31393.1; JOINED; Genomic_DNA.
DR EMBL; M21467; AAA31393.1; JOINED; Genomic_DNA.
DR PIR; A32283; A32283.
DR AlphaFoldDB; P20756; -.
DR SMR; P20756; -.
DR STRING; 9986.ENSOCUP00000007527; -.
DR eggNOG; ENOG502RYBQ; Eukaryota.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.10.320.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR000353; MHC_II_b_N.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00969; MHC_II_beta; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00921; MHC_II_beta; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF54452; SSF54452; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Adaptive immunity; Disulfide bond; Glycoprotein; Immunity; Membrane;
KW MHC II; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..257
FT /note="RLA class II histocompatibility antigen, DP beta
FT chain"
FT /id="PRO_0000019011"
FT TOPO_DOM 30..224
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 246..257
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 123..211
FT /note="Ig-like C1-type"
FT REGION 30..120
FT /note="Beta-1"
FT REGION 121..214
FT /note="Beta-2"
FT REGION 215..224
FT /note="Connecting peptide"
FT CARBOHYD 49
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 45..105
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 143..199
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 257 AA; 29090 MW; 60955374F2BD466C CRC64;
MRPCRSLRTA ALAVVLTVLL HPVALGRATP GESEQNYLWQ RRYECYASNG TQRLLDRCAY
NREEFVRFDS DIGEFRAVSE LGRQVAESWN LEYLQQARAE VDRVCRHNYE LFQGLPVLLQ
TQPRVSVSPS KKGPLQHHSL LVCHVTDFYP GHVQVRWFLN GREETAGVVS THPIHNGDWT
FQILVMLEMT PHQGDVYTCH VEHPSLDSPI TVEWKAQSDS ARSKMLAGVG GLVLGLVSLA
VGVFMHRRSK KAQQGCR
