ID   HBA1_ARCGA              Reviewed;         142 AA.
AC   P41329;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Hemoglobin subunit alpha-1;
DE   AltName: Full=Alpha-1-globin;
DE   AltName: Full=Hemoglobin alpha-1 chain;
DE   AltName: Full=Hemoglobin alpha-I chain;
OS   Arctocephalus galapagoensis (Galapagoes fur seal) (Arctocephalus australis
OS   galapagoensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Otariidae; Arctocephalus.
OX   NCBI_TaxID=30584;
RN   [1]
RP   PROTEIN SEQUENCE OF 2-142.
RX   PubMed=1910457; DOI=10.1007/bf01025624;
RA   Jahan M., Ahmed A., Trillmich F., Braunitzer G.;
RT   "The complete primary structure of the marine Carnivora, galapagoes fur
RT   seal (Arctocephalus galapagoensis, Otariidae) hemoglobins.";
RL   J. Protein Chem. 10:257-263(1991).
CC   -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; A61434; A61434.
DR   AlphaFoldDB; P41329; -.
DR   SMR; P41329; -.
DR   PRIDE; P41329; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08927; Hb-alpha-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002338; Hemoglobin_a-typ.
DR   InterPro; IPR002339; Hemoglobin_pi.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00612; ALPHAHAEM.
DR   PRINTS; PR00815; PIHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P0CH25"
FT   CHAIN           2..142
FT                   /note="Hemoglobin subunit alpha-1"
FT                   /id="PRO_0000052559"
FT   BINDING         59
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         88
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
SQ   SEQUENCE   142 AA;  15499 MW;  07B191ACCB3A5959 CRC64;
     MVLSPADKTN IKTTWDKLGG HAGEYGGEAL ERTFMSFPTT KTYFPHFDLS PGSAQVKAHG
     KKVADALTTA VAHMDDLPKA LSALSDLHAY KLRVDPVNFK LLSHCLLVTL ACHHPAEFTP
     AVHASLDKFF STVSTVLTSK YR