ID   HBA1_HAPGR              Reviewed;         140 AA.
AC   Q7M3B8;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Hemoglobin subunit alpha-1;
DE   AltName: Full=Alpha-1-globin;
DE   AltName: Full=Hemoglobin alpha-1 chain;
DE   Contains:
DE     RecName: Full=Hemopressin {ECO:0000250|UniProtKB:P01946};
GN   Name=HBA1;
OS   Hapalemur griseus (Gray gentle lemur) (Eastern lesser bamboo lemur).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Lemuridae; Hapalemur.
OX   NCBI_TaxID=13557;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2123766; DOI=10.1016/0305-0491(90)90278-2;
RA   Duffy L.K., Luick J., Coppenhaver D.H.;
RT   "Prosimian hemoglobins. V. The primary structures of the alpha-I, alpha-II
RT   and beta-hemoglobin chains of Hapalemur griseus, with a note on the
RT   classification of Microcebus.";
RL   Comp. Biochem. Physiol. 97B:261-267(1990).
CC   -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC       peripheral tissues.
CC   -!- FUNCTION: [Hemopressin]: Hemopressin acts as an antagonist peptide of
CC       the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks
CC       cannabinoid receptor CNR1 and subsequent signaling.
CC       {ECO:0000250|UniProtKB:P01946}.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; D60515; D60515.
DR   AlphaFoldDB; Q7M3B8; -.
DR   SMR; Q7M3B8; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08927; Hb-alpha-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002338; Hemoglobin_a-typ.
DR   InterPro; IPR002339; Hemoglobin_pi.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00612; ALPHAHAEM.
DR   PRINTS; PR00815; PIHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Transport.
FT   CHAIN           1..140
FT                   /note="Hemoglobin subunit alpha-1"
FT                   /id="PRO_0000052648"
FT   PEPTIDE         94..102
FT                   /note="Hemopressin"
FT                   /evidence="ECO:0000250|UniProtKB:P01946"
FT                   /id="PRO_0000455879"
FT   BINDING         57
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         86
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
SQ   SEQUENCE   140 AA;  15012 MW;  6BE55B616A42480A CRC64;
     VLSSADKTNI KTAWGAIGSH AADHGAEALE RMFLSFPTTK TYFPHFDMSH GSGQIAHGKK
     VADALTNAVG HIDDMPGALS ALSDLHAHKL RVDPVNFKLL SHCLLVTLAS HHPAEFTPAV
     HASLDKFFAA VSTVLTSKYR