ID   HBA1_OTOCR              Reviewed;         142 AA.
AC   P14259;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Hemoglobin subunit alpha-A;
DE   AltName: Full=Alpha-A-globin;
DE            Short=Alpha-I;
DE   AltName: Full=Hemoglobin alpha-A chain;
GN   Name=HBAA;
OS   Otolemur crassicaudatus (Brown greater galago) (Galago crassicaudatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=9463;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3586010; DOI=10.1016/0022-2836(86)90022-7;
RA   Sawada I., Schmid C.W.;
RT   "Primate evolution of the alpha-globin gene cluster and its Alu-like
RT   repeats.";
RL   J. Mol. Biol. 192:693-709(1986).
CC   -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; M29742; AAA35448.1; -; Genomic_DNA.
DR   PIR; A25597; A25597.
DR   AlphaFoldDB; P14259; -.
DR   SMR; P14259; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08927; Hb-alpha-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002338; Hemoglobin_a-typ.
DR   InterPro; IPR002339; Hemoglobin_pi.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00612; ALPHAHAEM.
DR   PRINTS; PR00815; PIHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Metal-binding; Oxygen transport; Transport.
FT   CHAIN           1..142
FT                   /note="Hemoglobin subunit alpha-A"
FT                   /id="PRO_0000052638"
FT   BINDING         59
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         88
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
SQ   SEQUENCE   142 AA;  15332 MW;  BC4F46BB70D139EB CRC64;
     MVLSPTDKSI VKAAWEKVGA HAGDYGAEAL ERMFLSFPTT KTYFPQFDLS HGSAQVKGHG
     KKVADALTNA VLHVDDMPSA LSALSDLHAH KLTVDPVNFK LLSHCLLVTL ACHLPAEFTP
     AVHASLDKFM ASVSTVLTSK YR