ID   HBA1_TADBR              Reviewed;         141 AA.
AC   P11755;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Hemoglobin subunit alpha-1;
DE   AltName: Full=Alpha-1-globin;
DE   AltName: Full=Hemoglobin alpha-1 chain;
OS   Tadarida brasiliensis (Brazilian free-tailed bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Molossidae;
OC   Tadarida.
OX   NCBI_TaxID=9438;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3113446; DOI=10.1515/bchm3.1987.368.1.681;
RA   Kleinschmidt T., Ruecknagel K.P., Weber R.E., Koop B.F., Braunitzer G.;
RT   "Primary structure and functional properties of the hemoglobin from the
RT   free-tailed bat Tadarida brasiliensis (Chiroptera). Small effect of carbon
RT   dioxide on oxygen affinity.";
RL   Biol. Chem. Hoppe-Seyler 368:681-690(1987).
CC   -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; A29391; A29391.
DR   AlphaFoldDB; P11755; -.
DR   SMR; P11755; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08927; Hb-alpha-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002338; Hemoglobin_a-typ.
DR   InterPro; IPR002339; Hemoglobin_pi.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00612; ALPHAHAEM.
DR   PRINTS; PR00815; PIHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Transport.
FT   CHAIN           1..141
FT                   /note="Hemoglobin subunit alpha-1"
FT                   /id="PRO_0000052775"
FT   BINDING         58
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         87
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
SQ   SEQUENCE   141 AA;  15252 MW;  A6CE1EDA7B722D18 CRC64;
     VLSPEDKNNV KAAWSKVGGQ AGDYGAEALE RMFLSFPTTK TYFPHFDLSH GSAQVKGHGK
     KVGEALTTAV NHMDDLPGAL STLSDLHAYK LRVDPVNFKL LSHCLLVTLA CHNPGEFTPA
     VHASLDKFLA SVSTVLTSKY R