HBA1_TRENE
ID HBA1_TRENE Reviewed; 142 AA.
AC P45718;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Hemoglobin subunit alpha-1;
DE AltName: Full=Alpha-1-globin;
DE AltName: Full=Hemoglobin alpha-1 chain;
GN Name=hba1;
OS Trematomus newnesi (Dusky notothen).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Notothenioidei; Nototheniidae; Trematomus.
OX NCBI_TaxID=35730;
RN [1]
RP PROTEIN SEQUENCE, ACETYLATION AT SER-1, FUNCTION, AND SUBUNIT.
RX PubMed=8144556; DOI=10.1016/s0021-9258(17)36935-1;
RA D'Avino R., Caruso C., Tamburrini M., Romano M., Rutigliano B.,
RA Polverino de Laureto P., Camardella L., Carratore V., di Prisco G.;
RT "Molecular characterization of the functionally distinct hemoglobins of the
RT Antarctic fish Trematomus newnesi.";
RL J. Biol. Chem. 269:9675-9681(1994).
CC -!- FUNCTION: Involved in oxygen transport from gills to the various
CC peripheral tissues. {ECO:0000269|PubMed:8144556}.
CC -!- SUBUNIT: Hb1 is a heterotetramer of two alpha-1 chains and two beta
CC chains. HbC is a heterotetramer of two alpha-1 chains and two beta-C
CC chains. {ECO:0000269|PubMed:8144556}.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- MISCELLANEOUS: This fish has three hemoglobins: Hb1 (major, about 65-
CC 70% of the total), Hb2 (about 5% of the total) and HbC (about 20-25% of
CC the total). Hb1 and Hb2 display a very weak Bohr effect and no Root
CC effect.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR PIR; A54403; A54403.
DR PDB; 1LA6; X-ray; 2.00 A; A=1-142.
DR PDB; 1T1N; X-ray; 2.20 A; A=1-142.
DR PDB; 2AA1; X-ray; 1.80 A; A/C=1-142.
DR PDB; 3D1K; X-ray; 1.25 A; A=1-142.
DR PDB; 3NFE; X-ray; 2.01 A; A/C=1-142.
DR PDB; 3NG6; X-ray; 2.20 A; A/C=1-142.
DR PDB; 5LFG; X-ray; 1.94 A; A/C=1-142.
DR PDBsum; 1LA6; -.
DR PDBsum; 1T1N; -.
DR PDBsum; 2AA1; -.
DR PDBsum; 3D1K; -.
DR PDBsum; 3NFE; -.
DR PDBsum; 3NG6; -.
DR PDBsum; 5LFG; -.
DR AlphaFoldDB; P45718; -.
DR SMR; P45718; -.
DR MINT; P45718; -.
DR iPTMnet; P45718; -.
DR EvolutionaryTrace; P45718; -.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08927; Hb-alpha-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002338; Hemoglobin_a-typ.
DR InterPro; IPR002339; Hemoglobin_pi.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00612; ALPHAHAEM.
DR PRINTS; PR00815; PIHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Direct protein sequencing; Heme; Iron;
KW Metal-binding; Oxygen transport; Transport.
FT CHAIN 1..142
FT /note="Hemoglobin subunit alpha-1"
FT /id="PRO_0000052787"
FT BINDING 59
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT BINDING 88
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT MOD_RES 1
FT /note="N-acetylserine"
FT /evidence="ECO:0000269|PubMed:8144556"
FT HELIX 4..17
FT /evidence="ECO:0007829|PDB:3D1K"
FT HELIX 18..20
FT /evidence="ECO:0007829|PDB:3D1K"
FT HELIX 21..35
FT /evidence="ECO:0007829|PDB:3D1K"
FT HELIX 37..43
FT /evidence="ECO:0007829|PDB:3D1K"
FT HELIX 54..72
FT /evidence="ECO:0007829|PDB:3D1K"
FT TURN 73..75
FT /evidence="ECO:0007829|PDB:3D1K"
FT HELIX 77..90
FT /evidence="ECO:0007829|PDB:3D1K"
FT HELIX 96..98
FT /evidence="ECO:0007829|PDB:3D1K"
FT HELIX 99..113
FT /evidence="ECO:0007829|PDB:3D1K"
FT TURN 115..117
FT /evidence="ECO:0007829|PDB:3D1K"
FT HELIX 120..137
FT /evidence="ECO:0007829|PDB:3D1K"
FT HELIX 138..140
FT /evidence="ECO:0007829|PDB:3D1K"
SQ SEQUENCE 142 AA; 15653 MW; 470CD779E9334A89 CRC64;
SLSDKDKAAV RALWSKIGKS SDAIGNDALS RMIVVYPQTK IYFSHWPDVT PGSPNIKAHG
KKVMGGIALA VSKIDDLKTG LMELSEQHAY KLRVDPSNFK ILNHCILVVI STMFPKEFTP
EAHVSLDKFL SGVALALAER YR
