HBA2_ALDGI
ID HBA2_ALDGI Reviewed; 142 AA.
AC P83132;
DT 01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Hemoglobin A subunit alpha-2;
DE AltName: Full=Hemoglobin A alpha-2 chain;
OS Aldabrachelys gigantea (Aldabra giant tortoise) (Geochelone gigantea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Aldabrachelys.
OX NCBI_TaxID=167804 {ECO:0000305};
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE OF 2-142.
RC TISSUE=Erythrocyte;
RA Shishikura F., Takami K.;
RT "The amino acid sequences of the alpha- and beta-globin chains of
RT hemoglobin from the Aldabra giant tortoises, Geochelone gigantea.";
RL Zool. Sci. 18:515-526(2001).
CC -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC peripheral tissues. {ECO:0000250|UniProtKB:P07417}.
CC -!- SUBUNIT: Tetramer of alpha-1, alpha-2 and two identical beta chains.
CC {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Red blood cells. {ECO:0000305}.
CC -!- MISCELLANEOUS: Hemoglobin A is the major, and hemoglobin D the minor
CC hemoglobin of this species. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR AlphaFoldDB; P83132; -.
DR SMR; P83132; -.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08927; Hb-alpha-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002338; Hemoglobin_a-typ.
DR InterPro; IPR002339; Hemoglobin_pi.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00612; ALPHAHAEM.
DR PRINTS; PR00815; PIHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|Ref.1"
FT CHAIN 2..142
FT /note="Hemoglobin A subunit alpha-2"
FT /id="PRO_0000052540"
FT BINDING 59
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT BINDING 88
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
SQ SEQUENCE 142 AA; 15805 MW; 9895ECB1E9B697D0 CRC64;
MVLTAGDKAN VKTVWSKVGS HLEDYGSETL ERLFVVYPST KTYFPHFDLH HDSPQVRAHG
KKVLSALGEA VNHIDDIPGA LSKLSDLHAQ NLRVDPVNFK LLNLCFVVVV GRHHPTILTP
EVHVSLDKFL SAVAQNLTSK YR