ID   AN13C_DANRE             Reviewed;         488 AA.
AC   Q7ZUV0;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Ankyrin repeat domain-containing protein 13C;
GN   Name=ankrd13c; ORFNames=zgc:56077;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a molecular chaperone for G protein-coupled
CC       receptors, regulating their biogenesis and exit from the ER.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}.
CC       Note=Associated with the cytosolic side. {ECO:0000250}.
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DR   EMBL; BC047821; AAH47821.1; -; mRNA.
DR   RefSeq; NP_999855.1; NM_214690.1.
DR   AlphaFoldDB; Q7ZUV0; -.
DR   SMR; Q7ZUV0; -.
DR   STRING; 7955.ENSDARP00000062236; -.
DR   PaxDb; Q7ZUV0; -.
DR   GeneID; 325167; -.
DR   KEGG; dre:325167; -.
DR   CTD; 81573; -.
DR   ZFIN; ZDB-GENE-030131-3892; ankrd13c.
DR   eggNOG; KOG0522; Eukaryota.
DR   InParanoid; Q7ZUV0; -.
DR   OrthoDB; 425969at2759; -.
DR   PhylomeDB; Q7ZUV0; -.
DR   PRO; PR:Q7ZUV0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0006621; P:protein retention in ER lumen; IBA:GO_Central.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR021832; ANKRD13.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   PANTHER; PTHR12447; PTHR12447; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF11904; GPCR_chapero_1; 1.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Chaperone; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Repeat.
FT   CHAIN           1..488
FT                   /note="Ankyrin repeat domain-containing protein 13C"
FT                   /id="PRO_0000240647"
FT   REPEAT          58..87
FT                   /note="ANK 1"
FT   REPEAT          90..119
FT                   /note="ANK 2"
FT   REPEAT          123..152
FT                   /note="ANK 3"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..31
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   488 AA;  55478 MW;  A5FD9B4D21699E03 CRC64;
     MTGEKIRSVR KERKSGLDLL EPDEEPAATG PAKHRGSKIF SGGNHRISRS SSSPGDPDGA
     YPVHECVFRG DVRRLSSLIR TQNIAQKDVH GNTPLHLAVM MGHKECAHLL LAHNAPVKVK
     NAQGWSPLAE AISYGDRQMI TALLRKLKQQ SRESVEDKRP RLLKALKELG DFYLELHWDF
     QSWVPLLSRI LPSDACKIYK QGINIRLDTT LIDFTDMKCQ RGDLSFIFCG DAPPSESFVV
     LDNEQKVYQR IHHEESEMET EEEVDILMSS DVYSATLSTK SITFSRAQTG WLFREDKTER
     VGNFLADFYM VNGLVLESRK RREHLSEEDI LRNKAIMESF SKGGSLIEQN FEPMRRQSLT
     PPSPNTISWE EYITAETGKA PHLGRELVCK ESKKNFKATV AMSPDFPLGI ESLLNVLEVI
     APFKHFNKLR EFVQMKLPPG FPVKLDIPVF PTITATVTFQ EFRYDEFDES IFTIPSDYKG
     DPSRFPDL