AN13C_MOUSE
ID AN13C_MOUSE Reviewed; 541 AA.
AC Q3UX43; B2RST2; Q6P1G4;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Ankyrin repeat domain-containing protein 13C;
GN Name=Ankrd13c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Egg;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Acts as a molecular chaperone for G protein-coupled
CC receptors, regulating their biogenesis and exit from the ER.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}.
CC Note=Associated with the cytosolic side. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3UX43-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3UX43-2; Sequence=VSP_019409, VSP_019410;
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DR EMBL; AK135906; BAE22720.1; -; mRNA.
DR EMBL; BY751496; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; CH466532; EDL11855.1; -; Genomic_DNA.
DR EMBL; BC065088; AAH65088.1; -; mRNA.
DR EMBL; BC138991; AAI38992.1; -; mRNA.
DR EMBL; BC138992; AAI38993.1; -; mRNA.
DR CCDS; CCDS17933.1; -. [Q3UX43-1]
DR RefSeq; NP_001013828.1; NM_001013806.1. [Q3UX43-1]
DR AlphaFoldDB; Q3UX43; -.
DR SMR; Q3UX43; -.
DR STRING; 10090.ENSMUSP00000038662; -.
DR iPTMnet; Q3UX43; -.
DR PhosphoSitePlus; Q3UX43; -.
DR EPD; Q3UX43; -.
DR MaxQB; Q3UX43; -.
DR PaxDb; Q3UX43; -.
DR PRIDE; Q3UX43; -.
DR ProteomicsDB; 282089; -. [Q3UX43-1]
DR ProteomicsDB; 282090; -. [Q3UX43-2]
DR Antibodypedia; 33431; 81 antibodies from 18 providers.
DR DNASU; 433667; -.
DR Ensembl; ENSMUST00000040787; ENSMUSP00000038662; ENSMUSG00000039988. [Q3UX43-1]
DR Ensembl; ENSMUST00000164582; ENSMUSP00000125831; ENSMUSG00000039988. [Q3UX43-1]
DR GeneID; 433667; -.
DR KEGG; mmu:433667; -.
DR UCSC; uc008rvk.1; mouse. [Q3UX43-1]
DR CTD; 81573; -.
DR MGI; MGI:2139746; Ankrd13c.
DR VEuPathDB; HostDB:ENSMUSG00000039988; -.
DR eggNOG; KOG0522; Eukaryota.
DR GeneTree; ENSGT00950000182928; -.
DR HOGENOM; CLU_026137_1_0_1; -.
DR InParanoid; Q3UX43; -.
DR OMA; YPMHQSV; -.
DR OrthoDB; 425969at2759; -.
DR PhylomeDB; Q3UX43; -.
DR TreeFam; TF314176; -.
DR BioGRID-ORCS; 433667; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Ankrd13c; mouse.
DR PRO; PR:Q3UX43; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q3UX43; protein.
DR Bgee; ENSMUSG00000039988; Expressed in saccule of membranous labyrinth and 260 other tissues.
DR ExpressionAtlas; Q3UX43; baseline and differential.
DR Genevisible; Q3UX43; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI.
DR GO; GO:0006621; P:protein retention in ER lumen; ISO:MGI.
DR GO; GO:2000209; P:regulation of anoikis; ISO:MGI.
DR GO; GO:0010469; P:regulation of signaling receptor activity; ISO:MGI.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR021832; ANKRD13.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR12447; PTHR12447; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF11904; GPCR_chapero_1; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; ANK repeat; Chaperone; Endoplasmic reticulum;
KW Membrane; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..541
FT /note="Ankyrin repeat domain-containing protein 13C"
FT /id="PRO_0000240646"
FT REPEAT 111..142
FT /note="ANK 1"
FT REPEAT 143..172
FT /note="ANK 2"
FT REPEAT 176..205
FT /note="ANK 3"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 411
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 237..249
FT /note="VPLLSRILPSDAC -> GKSVLRFIIKVQL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019409"
FT VAR_SEQ 250..541
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019410"
FT CONFLICT 69..111
FT /note="APAVPGPGVPAPPQHNAVTATCPAPACLGGSNPALVADGGGCP -> VSSEA
FT LARGAGERWLRRVFPSEEEAAAAAPGVVRSWSLELRLS (in Ref. 2;
FT BAE22720)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 541 AA; 60150 MW; F270FA45C62F2A7F CRC64;
MTGEKIRSLR RDHKPSKEDG DVLEPCEEEA TAALGGAFTG GRSGPGGSGK GGKACHKIFS
HHHRLQLKAP AVPGPGVPAP PQHNAVTATC PAPACLGGSN PALVADGGGC PSLYPVHECV
FKGDVRRLSS LIRTHNIGQK DNHGNTPLHL AVMLGNKECA HLLLAHNAPV KVKNAQGWSP
LAEAISYGDR QMITALLRKL KQQSRESVGE KRPRLLKALK ELGDFYLELH WDFQSWVPLL
SRILPSDACK IYKQGINIRL DTTLIDFTDM KCQRGDLSFI FNGDAAPSES FVVLDNEQKV
YQRIHHEESE METEEEVDIL MSSDIYSATL STKSISFTRA QTGWLFREDK TERVGNFLAD
FYLVNGLVLE SRKRREHLSE EDILRNKAIM ESLSKGGSLA EQSFEPVRRQ SLTPPPQNTI
TWEEYISAEN GKAPHLGREL VCKESKKTFK ATVAMSQEFP LGIESLLNVL EVIAPFKHFN
KLREFVQMKL PPGFPVKLDI PVFPTITATV TFQEFRCDEF DGSIFAIPED YKEDPSRFPD
L
