ID   AN13C_XENTR             Reviewed;         509 AA.
AC   Q28C34; Q0IHL1;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Ankyrin repeat domain-containing protein 13C;
GN   Name=ankrd13c; ORFNames=TEgg059p16.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Fat body;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a molecular chaperone for G protein-coupled
CC       receptors, regulating their biogenesis and exit from the ER.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}.
CC       Note=Associated with the cytosolic side. {ECO:0000250}.
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DR   EMBL; CR942477; CAJ81692.1; -; mRNA.
DR   EMBL; BC123102; AAI23103.1; -; mRNA.
DR   RefSeq; NP_001039126.1; NM_001045661.1.
DR   AlphaFoldDB; Q28C34; -.
DR   SMR; Q28C34; -.
DR   STRING; 8364.ENSXETP00000051005; -.
DR   PaxDb; Q28C34; -.
DR   GeneID; 733949; -.
DR   KEGG; xtr:733949; -.
DR   CTD; 81573; -.
DR   Xenbase; XB-GENE-5828071; ankrd13c.
DR   eggNOG; KOG0522; Eukaryota.
DR   InParanoid; Q28C34; -.
DR   OrthoDB; 425969at2759; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000009602; Expressed in 4-cell stage embryo and 12 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0006621; P:protein retention in ER lumen; IBA:GO_Central.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR021832; ANKRD13.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   PANTHER; PTHR12447; PTHR12447; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF11904; GPCR_chapero_1; 1.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Chaperone; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Repeat.
FT   CHAIN           1..509
FT                   /note="Ankyrin repeat domain-containing protein 13C"
FT                   /id="PRO_0000240650"
FT   REPEAT          79..110
FT                   /note="ANK 1"
FT   REPEAT          111..140
FT                   /note="ANK 2"
FT   REPEAT          144..173
FT                   /note="ANK 3"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   509 AA;  58144 MW;  A02976646E9EE65C CRC64;
     MTGEKIRSLH RDQKPSKDED LLEPDEEATA GGTFTRTGKL KNSKMFSNHK VIRSPSNPAL
     LQNHHQQISP ITPGESKTDA YFPVHECVFK GDIRRLSSLI RSHSIGQKDN HGNTPLHLAV
     MLGNKECAHL LLAHNAPVKV KNAQGWSPLA EAISYGDRQM ITALLRKLKQ QSRESVEEKR
     PRLLKALKEL GDFYLELHWD FQSWVPLLSR ILPSDACKIY KQGINIRLDT TLIDFTDMKC
     QRGDLSFIFN GDAAPSESFV VLDNEQKVYQ RIHHEESEME TEEEVDILMS SDIYSATLST
     KSISFTRAQT GWLFREDKTE RVGNFLADFH LVNGLILESR KRREHLTEED ILRNKAIMES
     LSKGGNLMEQ NFEPVRRQSL TPPPPNTITW EEYISAENGK APHLGRELVC KENKKTFKAT
     IAMSQDFPLG IESLLNVLEV IAPFKHFNKL REFVQMKLPP GFPVKLDIPV FPTITATVTF
     QEFRYGEFED AIFTIPDDYK EDPSRFPDL