ID   HBAD_CHRPI              Reviewed;         141 AA.
AC   P02005;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Hemoglobin subunit alpha-D;
DE   AltName: Full=Alpha-D-globin;
DE   AltName: Full=Hemoglobin alpha-D chain;
GN   Name=HBAD;
OS   Chrysemys picta bellii (Western painted turtle) (Emys bellii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC   Testudinoidea; Emydidae; Chrysemys.
OX   NCBI_TaxID=8478;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=6519642; DOI=10.1515/bchm2.1984.365.2.1163;
RA   Ruecknagel K.P., Reischl E., Braunitzer G.;
RT   "Hemoglobins of reptiles. Expression of alpha-D-genes in the turtles,
RT   Chrysemys picta bellii and Phrynops hilarii (Testudines).";
RL   Hoppe-Seyler's Z. Physiol. Chem. 365:1163-1171(1984).
RN   [2]
RP   PROTEIN SEQUENCE.
RX   PubMed=3365328; DOI=10.1515/bchm3.1988.369.1.123;
RA   Ruecknagel K.P., Braunitzer G.;
RT   "Hemoglobins of reptiles. The primary structure of the major and minor
RT   hemoglobin component of adult Western painted turtle (Chrysemys picta
RT   bellii).";
RL   Biol. Chem. Hoppe-Seyler 369:123-131(1988).
CC   -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha-D chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- DEVELOPMENTAL STAGE: In reptiles, the alpha-D chain occurs in a minor
CC       hemoglobin component, called hemoglobin d, which is expressed in late
CC       embryonic and adult life.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; A02332; HATTDP.
DR   RefSeq; XP_005306214.1; XM_005306157.1.
DR   AlphaFoldDB; P02005; -.
DR   SMR; P02005; -.
DR   Ensembl; ENSCPBT00000044692; ENSCPBP00000038114; ENSCPBG00000026396.
DR   GeneID; 101935124; -.
DR   KEGG; cpic:101935124; -.
DR   GeneTree; ENSGT00940000165231; -.
DR   OMA; HAAFDKF; -.
DR   OrthoDB; 1398217at2759; -.
DR   Proteomes; UP000694380; Unassembled WGS sequence.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08927; Hb-alpha-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002338; Hemoglobin_a-typ.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00612; ALPHAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..141
FT                   /note="Hemoglobin subunit alpha-D"
FT                   /id="PRO_0000052824"
FT   BINDING         58
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         87
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
SQ   SEQUENCE   141 AA;  16241 MW;  E4681DF8F8C17F3E CRC64;
     MLNHDEKQLI KHAWEKVLGH QEDFGAEALE RMFAVYPQTK TYFPHFDLHH DSEQIRHHGK
     KVVTALGDAV RHMDNLSEAL SELSNLHAYN LRVDPVNFKL LSHCFQVVLA VHLADEYTPQ
     VHVAYDKFLA AVSAVLAEKY R