ID   HBAD_COLLI              Reviewed;         140 AA.
AC   O12985;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Hemoglobin subunit alpha-D;
DE   AltName: Full=Alpha-D-globin;
DE   AltName: Full=Hemoglobin alpha-D chain;
GN   Name=HBAD;
OS   Columba livia (Rock dove).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX   NCBI_TaxID=8932;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9177291; DOI=10.1006/bbrc.1997.6667;
RA   Ikehara T., Eguchi Y., Kayo S., Takei H.;
RT   "Isolation and sequencing of two alpha-globin genes alpha(A) and alpha(D)
RT   in pigeon and evidence for embryo-specific expression of the alpha(D)-
RT   globin gene.";
RL   Biochem. Biophys. Res. Commun. 234:450-453(1997).
CC   -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha-D chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- DEVELOPMENTAL STAGE: In birds, the alpha-D chain occurs in a minor
CC       hemoglobin component, called hemoglobin d, which is expressed in late
CC       embryonic and adult life.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; AB001981; BAA19668.1; -; Genomic_DNA.
DR   PIR; JC5515; JC5515.
DR   RefSeq; XP_005508517.1; XM_005508460.1.
DR   AlphaFoldDB; O12985; -.
DR   SMR; O12985; -.
DR   STRING; 8932.XP_005508517.1; -.
DR   GeneID; 102090670; -.
DR   KEGG; clv:102090670; -.
DR   CTD; 102090670; -.
DR   eggNOG; KOG3378; Eukaryota.
DR   OrthoDB; 1398217at2759; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08927; Hb-alpha-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002338; Hemoglobin_a-typ.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00612; ALPHAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Metal-binding; Oxygen transport; Transport.
FT   CHAIN           1..140
FT                   /note="Hemoglobin subunit alpha-D"
FT                   /id="PRO_0000052825"
FT   BINDING         57
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         86
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
SQ   SEQUENCE   140 AA;  15717 MW;  2FAC884799A152F9 CRC64;
     MLTDSDKKLV LQVWEKVIRH PDCGAEALER LFTTYPQTKT YFPHFDLHHG SDQVRNHGKK
     VLAALGNAVK SLGNLSQALS DLSDLHAYNL RVDPVNFKLL AQCFHVVLAT HLGNDYTPEA
     HAAFDKFLSA VCTVLAEKYR