HBAE_ORYLA
ID HBAE_ORYLA Reviewed; 144 AA.
AC Q9PVU6;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Hemoglobin embryonic subunit alpha;
DE AltName: Full=Alpha-globin, embryonic;
DE AltName: Full=Hemoglobin alpha-chain, embryonic;
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Maruyama K., Yasumasu S., Iuchi I.;
RT "Medaka embryonic alpha-type globin.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in oxygen transport from gills to the various
CC peripheral tissues.
CC -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; AB026052; BAA85018.1; -; mRNA.
DR RefSeq; NP_001265827.1; NM_001278898.1.
DR RefSeq; NP_001265834.1; NM_001278905.1.
DR RefSeq; XP_011476181.1; XM_011477879.1.
DR AlphaFoldDB; Q9PVU6; -.
DR SMR; Q9PVU6; -.
DR STRING; 8090.ENSORLP00000006567; -.
DR Ensembl; ENSORLT00000006568; ENSORLP00000006567; ENSORLG00000005210.
DR Ensembl; ENSORLT00000006679; ENSORLP00000006678; ENSORLG00000005297.
DR Ensembl; ENSORLT00020008798; ENSORLP00020003940; ENSORLG00020004738.
DR GeneID; 101155030; -.
DR GeneID; 101174505; -.
DR KEGG; ola:101155030; -.
DR KEGG; ola:101174505; -.
DR eggNOG; KOG3378; Eukaryota.
DR GeneTree; ENSGT00940000163288; -.
DR HOGENOM; CLU_003827_10_2_1; -.
DR InParanoid; Q9PVU6; -.
DR OMA; VTIWAKV; -.
DR OrthoDB; 1398217at2759; -.
DR TreeFam; TF332328; -.
DR Proteomes; UP000001038; Chromosome 8.
DR Proteomes; UP000265180; Chromosome 8.
DR Proteomes; UP000265200; Unplaced.
DR Bgee; ENSORLG00000005210; Expressed in sexually immature organism and 10 other tissues.
DR GO; GO:0031838; C:haptoglobin-hemoglobin complex; IBA:GO_Central.
DR GO; GO:0005833; C:hemoglobin complex; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043177; F:organic acid binding; IBA:GO_Central.
DR GO; GO:0019825; F:oxygen binding; IBA:GO_Central.
DR GO; GO:0005344; F:oxygen carrier activity; IBA:GO_Central.
DR GO; GO:0098869; P:cellular oxidant detoxification; IEA:GOC.
DR GO; GO:0042744; P:hydrogen peroxide catabolic process; IBA:GO_Central.
DR CDD; cd08927; Hb-alpha-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002338; Hemoglobin_a-typ.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00612; ALPHAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 2: Evidence at transcript level;
KW Heme; Iron; Metal-binding; Oxygen transport; Reference proteome; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..144
FT /note="Hemoglobin embryonic subunit alpha"
FT /id="PRO_0000052711"
FT BINDING 61
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT BINDING 90
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
SQ SEQUENCE 144 AA; 15623 MW; CE4BDEFAC7D4C22C CRC64;
MTSLSAKDKD VVKAFWAKIS SKATDIGADA LGRMLVVYPQ TKTYFAHWKD LSPGSAPVKK
HGQTVMGGVA EAVGKIDNLT AGLLNLSELH AFTLRVDPAN FKILSHNILV VLAIMFPNDF
TPEVHVAMDK FLAALALALA EKYR