ID   HBAM_LITCT              Reviewed;         132 AA.
AC   P02022;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Hemoglobin heart muscle subunit alpha-type;
DE   AltName: Full=Hemoglobin alpha-type chain, heart muscle;
OS   Lithobates catesbeianus (American bullfrog) (Rana catesbeiana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX   NCBI_TaxID=8400;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=7037772; DOI=10.1016/s0021-9258(19)81035-9;
RA   Maeda N., Fitch W.M.;
RT   "Isolation and amino acid sequence of a monomeric hemoglobin in heart
RT   muscle of the bullfrog, Rana catesbeiana.";
RL   J. Biol. Chem. 257:2806-2815(1982).
CC   -!- FUNCTION: This hemoglobin may replace myocardial myoglobin in this
CC       amphibian species.
CC   -!- SUBUNIT: Monomer.
CC   -!- MISCELLANEOUS: This chain appears to have diverged from the line
CC       leading to alpha-type hemoglobin chains close to the divergence of
CC       alpha and beta chains.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; A02351; HAFGH.
DR   AlphaFoldDB; P02022; -.
DR   SMR; P02022; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002338; Hemoglobin_a-typ.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00612; ALPHAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Transport.
FT   CHAIN           1..132
FT                   /note="Hemoglobin heart muscle subunit alpha-type"
FT                   /id="PRO_0000052844"
FT   BINDING         58
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   BINDING         83
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
SQ   SEQUENCE   132 AA;  14391 MW;  70E36423397430DC CRC64;
     GLSDSEKSAV ASLWEKIAPQ TNKLGAESME RLFKNHPETK SFFSRFDISP GSQDLLTHGG
     KIFGALGEAI KSLDNLQKYQ DLHTNKLKLS SDHMKLLSAA IIEVFTAHFG GEVNQAAWNK
     FLGEVGAILT SS