ID   HBAP1_BOVIN             Reviewed;         484 AA.
AC   Q58CU3; Q0VCH5;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=HSPB1-associated protein 1;
DE   AltName: Full=27 kDa heat shock protein-associated protein 1;
GN   Name=HSPBAP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in cellular stress response. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CRYAB and HSPB1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q58CU3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q58CU3-2; Sequence=VSP_024440, VSP_024441;
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DR   EMBL; BT021854; AAX46701.1; -; mRNA.
DR   EMBL; BC120165; AAI20166.1; -; mRNA.
DR   RefSeq; NP_001014911.1; NM_001014911.1. [Q58CU3-1]
DR   AlphaFoldDB; Q58CU3; -.
DR   SMR; Q58CU3; -.
DR   STRING; 9913.ENSBTAP00000006679; -.
DR   PaxDb; Q58CU3; -.
DR   PRIDE; Q58CU3; -.
DR   Ensembl; ENSBTAT00000006679; ENSBTAP00000006679; ENSBTAG00000005066. [Q58CU3-1]
DR   GeneID; 513211; -.
DR   KEGG; bta:513211; -.
DR   CTD; 79663; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005066; -.
DR   eggNOG; KOG2132; Eukaryota.
DR   GeneTree; ENSGT00940000159893; -.
DR   HOGENOM; CLU_016785_5_1_1; -.
DR   InParanoid; Q58CU3; -.
DR   OrthoDB; 1385616at2759; -.
DR   TreeFam; TF315056; -.
DR   Proteomes; UP000009136; Chromosome 1.
DR   Bgee; ENSBTAG00000005066; Expressed in oocyte and 104 other tissues.
DR   ExpressionAtlas; Q58CU3; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016706; F:2-oxoglutarate-dependent dioxygenase activity; IBA:GO_Central.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR041667; Cupin_8.
DR   InterPro; IPR013296; HSPB1-associated_protein_1.
DR   InterPro; IPR003347; JmjC_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF13621; Cupin_8; 1.
DR   PRINTS; PR01886; PASS1.
DR   SMART; SM00558; JmjC; 1.
DR   PROSITE; PS51184; JMJC; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; Reference proteome; Stress response.
FT   CHAIN           1..484
FT                   /note="HSPB1-associated protein 1"
FT                   /id="PRO_0000284112"
FT   DOMAIN          124..288
FT                   /note="JmjC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00538"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          88..208
FT                   /note="Interaction with HSPB1"
FT                   /evidence="ECO:0000250"
FT   REGION          396..429
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        406..429
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         84..96
FT                   /note="APQFETACNYVEA -> GRTTRNRHRNVSS (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_024440"
FT   VAR_SEQ         97..484
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_024441"
SQ   SEQUENCE   484 AA;  54882 MW;  FA5C4B39702E4E21 CRC64;
     MAARPGAITN ADSASGGGEE EGKHVKPFTP EKAKEIIMCL QQPAVFYNMV FDWPAQHWTA
     KHLSEVLHGK QIRFRMGTKS TDTAPQFETA CNYVEATLEE FLSWNSDQSS ISGAFRDYDH
     SKFWAYADYK YFVSLFEDKT DIFQDVIWSD FGFPGRNGQE STLWIGSLGA HTPCHLDTYG
     CNLVFQVQGR KRWHLFPPED TPFLYPTRIP YEESSVFSKI NVVNPDLKRF PQFRKARRHM
     VTLSPGQVLF VPRHWWHYVE SIDPVTVSIN SWIELEEDHQ TRVEEAITRM LVCALKTAEN
     PHNTRAWLNP TELEETSHEI NCHYLNGAIS AFFNHYGTSE VVETQALRTN REYTIKEELN
     MHSHVGVEQA GGHNLSSETV KQEAASPFGL DLVPVTPSSE EPSSERGGIF ENDGEDFVSK
     NGKSFGKRQR MMSESENAVV EQIASDRTVA VSQTFVSTDD LLDCLVNPQV TRIVAQLLIQ
     GRST