ID   HBAP1_RAT               Reviewed;         479 AA.
AC   Q5BKC6; Q9R153;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=HSPB1-associated protein 1;
DE   AltName: Full=27 kDa heat shock protein-associated protein 1;
DE   AltName: Full=Protein associated with small stress protein 1;
GN   Name=Hspbap1; Synonyms=Pass1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CRYAB AND HSPB1,
RP   TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RC   STRAIN=Fischer; TISSUE=Sertoli cell;
RX   PubMed=10751411; DOI=10.1074/jbc.m001981200;
RA   Liu C., Gilmont R.R., Benndorf R., Welsh M.J.;
RT   "Identification and characterization of a novel protein from Sertoli cells,
RT   PASS1, that associates with mammalian small stress protein hsp27.";
RL   J. Biol. Chem. 275:18724-18731(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in cellular stress response.
CC       {ECO:0000269|PubMed:10751411}.
CC   -!- SUBUNIT: Interacts with CRYAB and HSPB1. {ECO:0000269|PubMed:10751411}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10751411}.
CC   -!- TISSUE SPECIFICITY: Widely expressed. Highly expressed by Sertoli cells
CC       in testis (at protein level). {ECO:0000269|PubMed:10751411}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD48846.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AF168362; AAD48846.1; ALT_FRAME; mRNA.
DR   EMBL; BC091125; AAH91125.1; -; mRNA.
DR   RefSeq; NP_599246.2; NM_134419.2.
DR   AlphaFoldDB; Q5BKC6; -.
DR   SMR; Q5BKC6; -.
DR   BioGRID; 251267; 1.
DR   STRING; 10116.ENSRNOP00000003060; -.
DR   iPTMnet; Q5BKC6; -.
DR   PhosphoSitePlus; Q5BKC6; -.
DR   jPOST; Q5BKC6; -.
DR   PaxDb; Q5BKC6; -.
DR   PRIDE; Q5BKC6; -.
DR   Ensembl; ENSRNOT00000003060; ENSRNOP00000003060; ENSRNOG00000002241.
DR   GeneID; 171460; -.
DR   KEGG; rno:171460; -.
DR   UCSC; RGD:620870; rat.
DR   CTD; 79663; -.
DR   RGD; 620870; Hspbap1.
DR   eggNOG; KOG2132; Eukaryota.
DR   GeneTree; ENSGT00940000159893; -.
DR   HOGENOM; CLU_016785_5_2_1; -.
DR   InParanoid; Q5BKC6; -.
DR   OMA; QRMMSKS; -.
DR   OrthoDB; 1385616at2759; -.
DR   PhylomeDB; Q5BKC6; -.
DR   TreeFam; TF315056; -.
DR   PRO; PR:Q5BKC6; -.
DR   Proteomes; UP000002494; Chromosome 11.
DR   Bgee; ENSRNOG00000002241; Expressed in adult mammalian kidney and 18 other tissues.
DR   ExpressionAtlas; Q5BKC6; baseline and differential.
DR   Genevisible; Q5BKC6; RN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016706; F:2-oxoglutarate-dependent dioxygenase activity; IBA:GO_Central.
DR   InterPro; IPR041667; Cupin_8.
DR   InterPro; IPR013296; HSPB1-associated_protein_1.
DR   InterPro; IPR003347; JmjC_dom.
DR   Pfam; PF13621; Cupin_8; 1.
DR   PRINTS; PR01886; PASS1.
DR   SMART; SM00558; JmjC; 1.
DR   PROSITE; PS51184; JMJC; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..479
FT                   /note="HSPB1-associated protein 1"
FT                   /id="PRO_0000284115"
FT   DOMAIN          124..288
FT                   /note="JmjC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00538"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          88..208
FT                   /note="Interaction with HSPB1"
FT                   /evidence="ECO:0000269|PubMed:10751411"
FT   REGION          347..412
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        371
FT                   /note="D -> E (in Ref. 1; AAD48846)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   479 AA;  54209 MW;  09144F7779CD6527 CRC64;
     MEAGCEGSSP QTLGERTMGE EGERVKPFTP EKAKEVIMSL QQPAIFCNMV FDWPSRHWTA
     KHLSKVLEGK QIRFRMGLRS TGTVPQFETE CSYVDATLEE FLAWNCDQSR ISGPFKKYDH
     SKFWAYADYK YFVTLFEDKT DVFQEVMWSD FGFPGRNGQE STLWIGSLGA HTPCHLDSYG
     CNLVFQVQGR KRWHLFPPED TPFLYPTRIP YEESSVFSKI NVVNPDLKRF PQFQKARRHM
     VTLSPGQVLF VPRHWWHYVE SLDPVTVSIN SWIELEEDHL ARVEEAVTRM LVCTLKTAED
     PHHPRTWLNP TEVEETSHEV NSCYLNSAVC AFFDHCERAK EVEMQAPRAN GEEPGVQEHM
     EVEQARDPSS DVGAGKQEAA SPFGPDLVPV TPASEERGGA LEGDSQECTS RNGEHCAELP
     CARRQQASKG ARAEAGQSAP RYPVAPSRVF VSTDDLLDCL VNPQVTRMVA QLLIQGKSL