ID   HBAZ_CAPHI              Reviewed;         142 AA.
AC   P13786;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Hemoglobin subunit zeta;
DE   AltName: Full=Hemoglobin zeta chain;
DE   AltName: Full=Zeta-globin;
GN   Name=HBZ1;
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3560223; DOI=10.1016/0022-2836(86)90269-x;
RA   Wernke S.M., Lingrel J.B.;
RT   "Nucleotide sequence of the goat embryonic alpha globin gene (zeta) and
RT   linkage and evolutionary analysis of the complete alpha globin cluster.";
RL   J. Mol. Biol. 192:457-471(1986).
CC   -!- FUNCTION: The zeta chain is an alpha-type chain of mammalian embryonic
CC       hemoglobin. {ECO:0000250}.
CC   -!- SUBUNIT: Heterotetramer of two zeta chains and beta-type chains.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; X04726; CAA28435.1; -; Genomic_DNA.
DR   EMBL; X04862; CAA28435.1; JOINED; Genomic_DNA.
DR   PIR; A25555; A25555.
DR   RefSeq; XP_017895578.1; XM_018040089.1.
DR   AlphaFoldDB; P13786; -.
DR   SMR; P13786; -.
DR   STRING; 9925.ENSCHIP00000019992; -.
DR   Ensembl; ENSCHIT00000027816; ENSCHIP00000019992; ENSCHIG00000018800.
DR   GeneID; 108633874; -.
DR   KEGG; chx:108633874; -.
DR   GeneTree; ENSGT00940000158623; -.
DR   OMA; AAMFPND; -.
DR   OrthoDB; 1398217at2759; -.
DR   Proteomes; UP000291000; Chromosome 25.
DR   Bgee; ENSCHIG00000018800; Expressed in uterus and 2 other tissues.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08927; Hb-alpha-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002338; Hemoglobin_a-typ.
DR   InterPro; IPR002340; Hemoglobin_zeta.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00612; ALPHAHAEM.
DR   PRINTS; PR00816; ZETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   3: Inferred from homology;
KW   Acetylation; Heme; Iron; Metal-binding; Oxygen transport; Phosphoprotein;
KW   Reference proteome; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P02008"
FT   CHAIN           2..142
FT                   /note="Hemoglobin subunit zeta"
FT                   /id="PRO_0000052849"
FT   BINDING         59
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         88
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02008"
FT   MOD_RES         29
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P02008"
FT   MOD_RES         53
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02008"
FT   MOD_RES         73
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02008"
FT   MOD_RES         82
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02008"
SQ   SEQUENCE   142 AA;  15697 MW;  C7538DF9047018E8 CRC64;
     MSLTRTERTI ILSLWSKIST QADVIGTETL ERLFSCYPQA KTYFPHFDLH SGSAQLRAHG
     SKVVAAVGDA VKSIDNVTSA LSKLSELHAY VLRVDPVNFK FLSHCLLVTL ASHFPADFTA
     DAHAAWDKFL SIVSGVLTEK YR