ID   HBAZ_HORSE              Reviewed;         142 AA.
AC   P13787;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Hemoglobin subunit zeta;
DE   AltName: Full=Hemoglobin zeta chain;
DE   AltName: Full=Zeta-globin;
GN   Name=HBZ1;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3351936; DOI=10.1016/0022-2836(88)90615-8;
RA   Flint J., Taylor A.M., Clegg J.B.;
RT   "Structure and evolution of the horse zeta globin locus.";
RL   J. Mol. Biol. 199:427-437(1988).
CC   -!- FUNCTION: The zeta chain is an alpha-type chain of mammalian embryonic
CC       hemoglobin. {ECO:0000250}.
CC   -!- SUBUNIT: Heterotetramer of two zeta chains and beta-type chains.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; X07051; CAA30095.1; -; Genomic_DNA.
DR   EMBL; X07052; CAA30096.1; -; Genomic_DNA.
DR   PIR; S01714; S01714.
DR   RefSeq; NP_001108014.1; NM_001114542.1.
DR   AlphaFoldDB; P13787; -.
DR   SMR; P13787; -.
DR   STRING; 9796.ENSECAP00000014183; -.
DR   PeptideAtlas; P13787; -.
DR   PRIDE; P13787; -.
DR   Ensembl; ENSECAT00000017453; ENSECAP00000014183; ENSECAG00000016460.
DR   GeneID; 100065056; -.
DR   KEGG; ecb:100065056; -.
DR   CTD; 3050; -.
DR   VGNC; VGNC:52395; HBZ.
DR   GeneTree; ENSGT00940000158623; -.
DR   InParanoid; P13787; -.
DR   OrthoDB; 1398217at2759; -.
DR   Proteomes; UP000002281; Chromosome 13.
DR   Bgee; ENSECAG00000016460; Expressed in trophoblast and 3 other tissues.
DR   GO; GO:0031838; C:haptoglobin-hemoglobin complex; IBA:GO_Central.
DR   GO; GO:0005833; C:hemoglobin complex; IBA:GO_Central.
DR   GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0043177; F:organic acid binding; IBA:GO_Central.
DR   GO; GO:0019825; F:oxygen binding; IBA:GO_Central.
DR   GO; GO:0005344; F:oxygen carrier activity; IBA:GO_Central.
DR   GO; GO:0098869; P:cellular oxidant detoxification; IEA:GOC.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IBA:GO_Central.
DR   CDD; cd08927; Hb-alpha-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002338; Hemoglobin_a-typ.
DR   InterPro; IPR002340; Hemoglobin_zeta.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00612; ALPHAHAEM.
DR   PRINTS; PR00816; ZETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   3: Inferred from homology;
KW   Acetylation; Heme; Iron; Metal-binding; Oxygen transport; Phosphoprotein;
KW   Reference proteome; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P02008"
FT   CHAIN           2..142
FT                   /note="Hemoglobin subunit zeta"
FT                   /id="PRO_0000052850"
FT   BINDING         59
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         88
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02008"
FT   MOD_RES         53
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02008"
FT   MOD_RES         73
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02008"
SQ   SEQUENCE   142 AA;  15563 MW;  20217A19AE85A07E CRC64;
     MSLTKAERTM VVSIWGKISM QADAVGTEAL QRLFSSYPQT KTYFPHFDLH EGSPQLRAHG
     SKVAAAVGDA VKSIDNVAGA LAKLSELHAY ILRVDPVNFK FLSHCLLVTL ASRLPADFTA
     DAHAAWDKFL SIVSSVLTEK YR