AN18B_HUMAN
ID AN18B_HUMAN Reviewed; 1011 AA.
AC A2A2Z9;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Ankyrin repeat domain-containing protein 18B;
GN Name=ANKRD18B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL139008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A2A2Z9; -.
DR SMR; A2A2Z9; -.
DR IntAct; A2A2Z9; 1.
DR MINT; A2A2Z9; -.
DR STRING; 9606.ENSP00000290943; -.
DR iPTMnet; A2A2Z9; -.
DR PhosphoSitePlus; A2A2Z9; -.
DR BioMuta; ANKRD18B; -.
DR EPD; A2A2Z9; -.
DR jPOST; A2A2Z9; -.
DR MassIVE; A2A2Z9; -.
DR MaxQB; A2A2Z9; -.
DR PaxDb; A2A2Z9; -.
DR PeptideAtlas; A2A2Z9; -.
DR PRIDE; A2A2Z9; -.
DR ProteomicsDB; 240; -.
DR Antibodypedia; 57403; 58 antibodies from 9 providers.
DR Ensembl; ENST00000290943.10; ENSP00000290943.6; ENSG00000230453.10.
DR UCSC; uc064spz.1; human.
DR GeneCards; ANKRD18B; -.
DR HGNC; HGNC:23644; ANKRD18B.
DR HPA; ENSG00000230453; Group enriched (brain, choroid plexus).
DR MIM; 618930; gene.
DR neXtProt; NX_A2A2Z9; -.
DR OpenTargets; ENSG00000230453; -.
DR VEuPathDB; HostDB:ENSG00000230453; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000163510; -.
DR HOGENOM; CLU_001111_0_0_1; -.
DR InParanoid; A2A2Z9; -.
DR OMA; ELLLCWA; -.
DR PhylomeDB; A2A2Z9; -.
DR TreeFam; TF333496; -.
DR PathwayCommons; A2A2Z9; -.
DR SignaLink; A2A2Z9; -.
DR Pharos; A2A2Z9; Tdark.
DR PRO; PR:A2A2Z9; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; A2A2Z9; protein.
DR Bgee; ENSG00000230453; Expressed in cerebellar cortex and 99 other tissues.
DR ExpressionAtlas; A2A2Z9; baseline and differential.
DR Genevisible; A2A2Z9; HS.
DR Gene3D; 1.25.40.20; -; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR039497; CC144C-like_CC_dom.
DR InterPro; IPR021885; DUF3496.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF14915; CCDC144C; 1.
DR Pfam; PF12001; DUF3496; 1.
DR SMART; SM00248; ANK; 5.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 4.
PE 1: Evidence at protein level;
KW ANK repeat; Coiled coil; Reference proteome; Repeat.
FT CHAIN 1..1011
FT /note="Ankyrin repeat domain-containing protein 18B"
FT /id="PRO_0000317245"
FT REPEAT 67..96
FT /note="ANK 1"
FT REPEAT 100..129
FT /note="ANK 2"
FT REPEAT 133..162
FT /note="ANK 3"
FT REPEAT 166..195
FT /note="ANK 4"
FT REPEAT 199..228
FT /note="ANK 5"
FT REGION 264..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 277..319
FT /evidence="ECO:0000255"
FT COILED 385..639
FT /evidence="ECO:0000255"
FT COILED 692..722
FT /evidence="ECO:0000255"
FT COILED 752..908
FT /evidence="ECO:0000255"
FT COMPBIAS 278..293
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..330
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1011 AA; 118231 MW; 9DC98BDDD988B735 CRC64;
MRKLLSFGRR LGQALLSSMD QEYAGRGYHI RDWELRKIHR AAIKGDAAEV EHCLTRRFRD
LDVRDRKDRT VLHLACAHGR VQVVTLLLDR KCQINICDRL NRTPLMKAVH CQEEACAIIL
LKRGANPNIK DIYGNTALHY AVYNEGTSLA ERLLSHHANI EALNKEGNTP LLFAINSRRQ
HMVEFLLKNQ ANIHAVDNFK RTALILAVQH NLSSIVTLLL QQNIHISSQD MFGQTAEDYA
FCCDLRSIQQ QILEHKNKML KNHLRNDNQE TAAMKPENLK KRKKRKKLKK RKEGAKAEHN
LKVASEEKQE RLERSENKQP QDSQSYGKKK DEMFGNFMLK RDIAMLKEEL YAIKNDSLRK
EKKYIQEIKS ITEINANFEK SVRLNEEMIT KKVAQYSQQL NDLKAENARL NSKLEKEKHN
KERLEAEVES LHSNLATAIN EYNEILERKD LELVLWRADD VSRHETMGSN ISQLTDKNEL
LTEQVHKARV KFNTLKGKLR ETRDALREKT LALESVQLDL KQAQHRIKEM KQMHPNGEAK
ESQSIGKQNS SEERIRQREL ENLLLERQLE DARKEGDNKE IVINIHRDCL ENGKEDLLEE
RNKELMNEYN YLKEKLLQYE KEKAEREVIV REFQEELVDH LKKFSMSESP LEGTSHCHIN
LDETWTSKKK LFQVEIQPEE KHEEFRKVFE LISLLNYTAD QIRKKNRELE EEATGYKKCL
EMTINMLNAF ANEDFSCHGD LNTDQLKMDI LFKKLKQKFD DLMAEKEAVS SKCVNLAKDN
EVLHQELLSM GKVQEKCEKL EKDKKMLEEK VLNLKTHMEK DMVELGKVQE YKSELDERAM
QAIEKLEEIH LQKQAEYEKQ LEQLNKDNTA SLKKKELTLK DVECKFSKMK TAYEDVTTEL
EEYKEAFAVA LKANSSMSEK ITKSDKKIAV ISTKLFMEKE RMEYFLSTLP MRPDPELPCV
ENLNSIELNR KYIPKMAIRI PTSNPQTSNN CKNSLTELLL RWALAPIYFL L
