HBAZ_PIG
ID HBAZ_PIG Reviewed; 141 AA.
AC P02009;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Hemoglobin subunit zeta;
DE AltName: Full=Hemoglobin zeta chain;
DE AltName: Full=Zeta-globin;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP PROTEIN SEQUENCE, ACETYLATION AT SER-1, FUNCTION, AND SUBUNIT.
RX PubMed=6724525;
RA Bieber F.A., Braunitzer G.;
RT "Pre- and perinatal oxygen transport in mammals: the embryonic hemoglobins
RT of the domestic pig (Sus scrofa domestica).";
RL Hoppe-Seyler's Z. Physiol. Chem. 365:321-334(1984).
CC -!- FUNCTION: The zeta chain is an alpha-type chain of mammalian embryonic
CC hemoglobin. {ECO:0000269|PubMed:6724525}.
CC -!- SUBUNIT: Heterotetramer of two zeta chains and two epsilon chains.
CC {ECO:0000269|PubMed:6724525}.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR PIR; A02338; HZPG.
DR AlphaFoldDB; P02009; -.
DR SMR; P02009; -.
DR STRING; 9823.ENSSSCP00000008514; -.
DR iPTMnet; P02009; -.
DR PaxDb; P02009; -.
DR PeptideAtlas; P02009; -.
DR eggNOG; KOG3378; Eukaryota.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0031838; C:haptoglobin-hemoglobin complex; IBA:GO_Central.
DR GO; GO:0005833; C:hemoglobin complex; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0043177; F:organic acid binding; IBA:GO_Central.
DR GO; GO:0019825; F:oxygen binding; IBA:GO_Central.
DR GO; GO:0005344; F:oxygen carrier activity; IBA:GO_Central.
DR GO; GO:0098869; P:cellular oxidant detoxification; IEA:GOC.
DR GO; GO:0042744; P:hydrogen peroxide catabolic process; IBA:GO_Central.
DR CDD; cd08927; Hb-alpha-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002338; Hemoglobin_a-typ.
DR InterPro; IPR002340; Hemoglobin_zeta.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00612; ALPHAHAEM.
DR PRINTS; PR00816; ZETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW Acetylation; Direct protein sequencing; Heme; Iron; Metal-binding;
KW Oxygen transport; Phosphoprotein; Reference proteome; Transport.
FT CHAIN 1..141
FT /note="Hemoglobin subunit zeta"
FT /id="PRO_0000052855"
FT BINDING 58
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT BINDING 87
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT MOD_RES 1
FT /note="N-acetylserine"
FT /evidence="ECO:0000269|PubMed:6724525"
FT MOD_RES 28
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P02008"
FT MOD_RES 52
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02008"
FT MOD_RES 72
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02008"
SQ SEQUENCE 141 AA; 15403 MW; 79CB4AAE8B7AD0E4 CRC64;
SLTKAERTII GSMWTKISSQ ADTIGTETLE RLFASYPQAK TYFPHFDLNP GSAQLRAHGS
KVLAAVGEAV KSIDNVSAAL AKLSELHAYV LRVDPVNFKF LSHCLLVTLA SHFPADLTAE
AHAAWDKFLT IVSGVLTEKY R
